Pulmonology Book

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Benzonatate

Aka: Benzonatate, Tessalon, Tessalon Perles
  1. See Also
    1. Cough Suppressant
    2. Benzonatate Overdose
  2. Background
    1. First approved for use in U.S. in 1958
    2. Synthetic butylamino-benzoate derivative (related to tetracaine, procaine)
      1. Voltage-gated Sodium channel inhibitor
    3. Peripherally acting non-opioid Antitussive
    4. Decreases cough reflex by anesthetizing and suppressing stretch receptors receptors in the airways, lungs, and pleura
    5. Narrow therapeutic range
      1. See Benzonatate Overdose
      2. Single capsule may be lethal in a child
      3. A small handful of capsules in Overdose could be lethal in adults
  3. Dosing
    1. Adults: 100-200 mg orally every 8 hours as needed for cough
    2. Not approved for age under 10 years old
  4. Pharmacokinetics
    1. Onset: 15-20 minutes
    2. Duration: 3-8 hours
  5. Adverse Effects
    1. Nausea
    2. Dizziness
    3. Headache
    4. Sedation or Somnolence
    5. Tongue numbness
  6. Precautions: Toxicology
    1. See Benzonatate Overdose
Medication Costs
Benzonatate (on 6/18/2017 at Walmart.com)
Benzonatate 100mg #14 capsules for $4.00 $0.29 each
Benzonatate 100mg #42 capsules for $10.00 $0.24 each
benzonatate (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
BENZONATATE 100 MG CAPSULE Generic $0.20 each
BENZONATATE 200 MG CAPSULE Generic $0.30 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

benzonatate (C0053229)

Definition (NCI) A synthetic butylamino-benzoate derivative related to tetracaine and a peripherally acting antitussive, nonnarcotic Benzonatate reduces the cough reflex by anesthetizing and depressing mechanoreceptors in the respiratory passages, lungs, and pleura. It is recommended for cough relief in the common cold, bronchitis, pneumonia, and for chronic cough such as in asthma. (NCI04)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C029755
SnomedCT 31801005, 386030001
LNC LP18904-0, MTHU006813
English benzonatate, benzonatate (medication), BENZONATATE, benzonatate [Chemical/Ingredient], Benzonatate, Benzonatate (product), Benzonatate (substance)
Spanish benzonatato (producto), benzonatato (sustancia), benzonatato
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Tessalon Perles (C0723653)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Tessalon Perles, tessalon perle, tessalon perles
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Tessalon (C0740256)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C029755
English Tessalon, tessalon
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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