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Sweat Chloride
Aka: Sweat Chloride, Sweat Test
- See Also
- Delta F508
- Indication
- Cystic Fibrosis testing
- Method
- Quantitative Pilocarpine Iontophoresis
- Stimulates local sweat production (parasympathetic)
- Collect sweat on gauze pads
- Analyze Sodium and chloride content
- Minimum sweat amount required: 50 mg (200 mg better)
- Normal
- Sweat contains <60 meq/Liter Chloride and Sodium
- Abnormal Results
- CF Sweat contains > 70 meq/L Chloride and Sodium
- Error: >30 meq/L difference between chloride and Sodium
- Indications to repeat the test for confirmation
- Positive Test
- Suspected False Negative
-
False Positive Tests
- Glucose 6 phosphate dehydrogenase deficiency (G6PD)
- Hypothyroidism
- Glycogen Storage Disease
- Untreated Adrenal Insufficiency
- Malnutrition
- Reference
- Bakerman (1984) ABC's of Lab Data, ILD, Greenville, NC