Pulmonology Book

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Small Cell Lung Cancer

Aka: Small Cell Lung Cancer
  1. See Also
    1. Lung Cancer
    2. Non-Small Cell Lung Cancer
  2. Background
    1. Accounts for 15-20% of Lung Cancers
    2. Central, large cancers with Lymphadenopathy
    3. Associated with paraneoplastic syndromes
  3. Staging
    1. TNM Staging System
      1. Recommended by American College of Chest Physicians (ACCP)
      2. Staging Calculator
        1. http://staginglungcancer.org/calculator
    2. Veterans Administration Lung Study Group Classification System
      1. Limited: Lesion confined to ipsilateral chest
      2. Extensive: Metastases beyond ipsilateral chest
  4. Management
    1. Available Therapy
      1. Chemotherapy
        1. Cisplatin (or carboplatin if significant Chronic Kidney Disease)
        2. Etoposide (Etopophos)
      2. Radiation Therapy
        1. Consolidative Thoracic Radiation
          1. Considered in patients with residual localized Lung Lesions responding to Chemotherapy
        2. Cranial Irradiation
          1. Prophylactic for brain metastases in limited stage SCLC (reduces mortality)
        3. Localized palliative radiation
          1. Non-pulmonary metastases
        4. Whole brain Radiotherapy
          1. Brain metastases
    2. Limited stage
      1. Intent to cure management is associated with a 25% five year survival
      2. Chemotherapy with concurrent Radiotherapy (see above)
      3. Surgical resection of localized lesions may be indicated
    3. Extensive stage
      1. Five year survival approaches 0% (two year survival <10%)
      2. Chemotherapy with Immunotherapy for 4 to 6 cycles
      3. Maintenance Immunotherapy after initial cycles
      4. Radiation Therapy as above
    4. Other measures
      1. Cranial Irradiation
        1. Prophylactic cranial irradiation improves survival
        2. Auperin (1999) N Engl J Med 341:476-84 [PubMed]
  5. References
    1. Kim (2022) Am Fam Physician 105(5): 487-94 [PubMed]
    2. Latimer (2015) Am Fam Physician 91(4): 250-6 [PubMed]

Small cell carcinoma of lung (C0149925)

Definition (MSH) A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Definition (MSHCZE) Forma vysoce maligního nádoru plic, který se skládá z malých elipsovitých buněk (KARCINOM MALOBUNĚČNÝ). R
Definition (NCI) A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis.
Definition (NCI_NCI-GLOSS) An aggressive (fast-growing) cancer that forms in tissues of the lung and can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.
Definition (CSP) radiosensitive tumor composed of small, oval, undifferentiated cells that are intensely hematoxyphilic and typically bronchogenic.
Concepts Neoplastic Process (T191)
MSH D055752
SnomedCT 254633006, 254632001
English PULMONARY SMALL CELL CARCINOMA <OAT CELL>, SCLC1, SCLC, SCCL, SMALL CELL CANCER OF THE LUNG, small cell carcinoma of lung (diagnosis), small cell carcinoma of lung, Small Cell Lung Cancer, Oat Cell Carcinoma of Lung, Oat Cell Lung Cancer, Carcinoma, Small Cell Lung, Small Cell Lung Carcinoma, PULMONARY SMALL CELL CARCINOMA OAT CELL, Small Cell Lung Carcinoma [Disease/Finding], small cell lung cancer (SCLC), cancer cell lung oat, cancer cell lung small, small cell carcinoma, small cell lung carcinoma, lung cancer oat cell, oat cell carcinoma of lung, oat cell cancer, sclc, small cell carcinoma of the lung, Small Cell Cancer Of The Lung, Small cell lung cancer stage unspecified, Small cell carcinoma of the lung, lung malignant carcinoma oat cell, lung malignant carcinoma oat cell (diagnosis), Oat cell carcinoma of lung, SCLC - Small cell lung cancer, Small cell lung cancer, Oat cell carcinoma of lung (disorder), Small cell carcinoma of lung (disorder), lung cancer, small cell, oat cell lung cancer, small cell lung cancer, Lung cancer, small cell, Small cell carcinoma of lung, Lung Oat Cell Carcinoma, Lung Small Cell Neuroendocrine Carcinoma, Oat Cell Carcinoma of the Lung, Oat Cell Lung Carcinoma, Small Cell Carcinoma of Lung, Small Cell Carcinoma of the Lung, Small Cell Neuroendocrine Carcinoma of Lung, Small Cell Neuroendocrine Carcinoma of the Lung
Spanish Carcinoma de Células en Grano de Avena del Pulmón, Carcinoma Pulmonar de Células Pequeñas, Cáncer de pulmón de células pequeñas, estadio no especificado, Carcinoma de células pequeñas de pulmón, Cáncer de pulmón de células pequeñas, Carcinoma de Células Pequeñas del Pulmón, Carcinoma de Células en Avena del Pulmón, Carcinoma de Pulmón de Células en Avena, carcinoma de células en grano de avena de pulmón (trastorno), carcinoma de células en grano de avena de pulmón, carcinoma de células pequeñas de pulmón (trastorno), carcinoma de células pequeñas de pulmón, carcinoma pulmonar de células en grano de avena, carcinoma pulmonar de células pequeñas
French Cancer du poumon à cellules en grains d'avoine, Carcinome du poumon à cellules en grains d'avoine, Cancer du poumon à petites cellules, Carcinome pulmonaire à petites cellules, Carcinome bronchique à petites cellules, Carcinome broncho-pulmonaire à petites cellules, Cancer bronchique à petites cellules, Cancer broncho-pulmonaire à petites cellules, Carcinome du poumon à petites cellules, Cancer bronchopulmonaire à petites cellules, Cancer du poumon à petites cellules stade non précisé
Italian Carcinoma del polmone a piccole cellule, Tumore del polmone a piccole cellule, Cancro del polmone a piccole cellule, Carcinoma a piccole cellule del polmone, Cancro a piccole cellule polmonare, Cancro a piccole cellule polmonare, stadio non specificato
Russian OVSIANOKLETOCHNYI RAK LEGKOGO, KARTSINOMA LEGKOGO MELKOKLETOCHNAIA, ОВСЯНОКЛЕТОЧНЫЙ РАК ЛЕГКОГО, КАРЦИНОМА ЛЕГКОГО МЕЛКОКЛЕТОЧНАЯ
German Kleinzelliges Lungenkarzinom, Lungenkarzinom, kleinzelliges, kleinzelliges Lungenkarzinom, kleinzelliges Karzinom der Lunge, kleinzelliges Lungenkarzinom Stadium unbekannt
Portuguese Carcinoma de Pequenas Células do Pulmão, Carcinoma tipo Oat Cell do Pulmão, Carcinoma de pequenas células do pulmão, Cancro pulmonar de células pequens estádio não especificado, Cancro pulmonar de pequenas células, Carcinoma de Células em Grão de Aveia do Pulmão, Carcinoma Avenocelular do Pulmão, Carcinoma Indiferenciado de Pequenas Células do Pulmão
Swedish Småcelligt lungkarcinom
Czech malobuněčný karcinom plic, karcinom ovískový, SCLC, Malobuněčný karcinom plic, Malobuněčné maligní nádorové onemocnění plic, Malobuněčné maligní nádorové onemocnění plic blíže neurčeného stadia
Polish Rak drobnokomórkowy płuc, Rak płuc drobnokomórkowy
Japanese 小細胞性肺癌, 肺癌-小細胞, 肺小細胞癌, 肺癌-燕麦細胞, 燕麦細胞肺癌, 小細胞肺がん, 小細胞肺癌, ｼｮｳｻｲﾎﾞｳﾊｲｶﾞﾝﾋﾞｮｳｷﾌﾒｲ, ｼｮｳｻｲﾎﾞｳﾊｲｶﾞﾝ, 小細胞肺癌、病期不明
Dutch kleincellige longkanker, kleincelcarcinoom van de long, kleincellige longkanker stadium niet-gespecificeerd
Hungarian Tüdő kissejtes carcinomája, Kis sejtes nem meghatározott stádiumú tüdőrák, Kissejtes tüdőrák
Norwegian Småcellet lungekarsinom, Småcellet lungekreft, Lungekarsinom, småcellet
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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