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Nonasthmatic Eosinophilic Bronchitis
Aka: Nonasthmatic Eosinophilic Bronchitis, Eosinophilic Bronchitis
- See Also
- Chronic Cough
- Epidemiology
- Emerging cause of Chronic Cough in pulmonology clinics
- Responsible for 10-30% of Chronic Cough cases referred to pulmonology
- Differential Diagnosis
- See Chronic Cough Causes
- Asthma
- Diagnosis
- Normal airway hyper-responsiveness (i.e. not Asthma)
- Normal Spirometry
- Normal airway responsiveness on methacholine inhalation test
- Sputum Eosinophilia (i.e. not Chronic Bronchitis)
- Induced Sputum (via saline nebulization) with 3% or more Eosinophils
- No signs variable airflow obstruction
- Management
- Does not respond to Inhaled Bronchodilators
- Eliminate Occupational Lung Disease and inhaled allergan exposures
- High-dose Inhaled Corticosteroids
- Brief initial course of Systemic Corticosteroids may be considered if Inhaled Corticosteroids ineffective
- References
- Brightling (1999) Am J Respir Crit Care Med 160(2): 406-10 [PubMed]
- Brightling (2010) Lung 188(suppl 1): S13-17 [PubMed]