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Sulfonamide Allergy
Aka: Sulfonamide Allergy, Sulfa Allergy
- See Also
- Sulfonamide
- Pharmacology
- Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
- Sulfonamide Allergy does not cross react with sulfur, sulfate, Sulfites
- Preparations: Sulfonylarylamines (Sulfa agents)
- General
- Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
- Sulfa Antibiotics
- Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
- Sulfadiazine
- Sulfacetamide
- Sulfa Antiinflammatories
- Sulfasalazine
- Protease Inhibitors (HIV Infection)
- Darunavir (Prezista)
- Fosamprenavir (Lexiva)
- Preparations: Non-Sulfonylarylamines
- General
- Similar structure to Sulfonylarylamines , but Hypersensitivity cross-reactivity is uncommon
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
- Diuretics
- All Thiazide Diuretics
- Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
- Anti-hyperglycemics (Diabetes Mellitus)
- Sulfonylureas (e.g. Glipizide)
- Analgesics
- Celecoxib (Celebrex)
- Preparations: Sulfonamide Moieties
- General
- Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
- However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
- Neurologic agents
- Sumatriptan (Imitrex)
- Topiramate (Topamax)
- Zonisamide (Zonagran)
- Protease Inhibitor (Hepatitis C Infection)
- Simeprevir (Olysio)
- References
- (2014) Presc Lett 21(2): 10-11
- Ghimire (2013) J Clin Pharm Ther 38: 196–202 [PubMed]
- Wulf (2013) Am J Health Syst Pharm 70:1483-94 [PubMed]