Sulfonamide Allergy

Aka: Sulfonamide Allergy, Sulfa Allergy

1. See Also
   1. Sulfonamide
2. Pharmacology
   1. Hypersensitivity to Sulfonamide groups most affects Sulfonylarylamines, but can affect Non-Sulfonylarylamines and Sulfonamide Moieties
   2. Sulfonamide Allergy does not cross react with sulfur, sulfate, Sulfites
3. Preparations: Sulfonylarylamines (Sulfa agents)
   1. General
      1. Typical sulfa-allergens, with greatest cross-reactivity to other sulfa agents
   2. Sulfa Antibiotics
      1. Trimethoprim-Sulfamethoxazole (Bactrim, Sulfatrim, Co-trimoxazole, Septra)
      2. Sulfadiazine
      3. Sulfacetamide
   3. Sulfa Antiinflammatories
      1. Sulfasalazine
   4. Protease Inhibitors (HIV Infection)
      1. Darunavir (Prezista)
      2. Fosamprenavir (Lexiva)
4. Preparations: Non-Sulfonylarylamines
   1. General
      1. Similar structure to Sulfonylarylamines , but hypersensitivity cross-reactivity is uncommon
      2. However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
   2. Diuretics
      1. All Thiazide Diuretics
      2. Some Loop Diuretics (Furosemide, Torsemide, Bumetanide)
   3. Anti-hyperglycemics (Diabetes Mellitus)
      1. Sulfonylureas (e.g. Glipizide)
   4. Analgesics
      1. Celecoxib (Celebrex)
5. Preparations: Sulfonamide Moieties
   1. General
      1. Differ significantly from Sulfonylarylamines (despite both having Sulfonamide group)
      2. However, do not use non-Sulfonylarylamines if history of Anaphylaxis or Erythema Multiforme Major to sulfa agents
   2. Neurologic agents
      1. Sumatriptan (Imitrex)
      2. Topiramate (Topamax)
      3. Zonisamide (Zonagran)
   3. Protease Inhibitor (Hepatitis C Infection)
      1. Simeprevir (Olysio)
6. References
   1. (2014) Presc Lett 21(2): 10-11
   2. Ghimire (2013) J Clin Pharm Ther 38: 196–202 [PubMed]
   3. Wulf (2013) Am J Health Syst Pharm 70:1483-94 [PubMed]