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Second Generation Broad-spectrum Cephalosporins
Aka: Second Generation Broad-spectrum Cephalosporins, Second Generation Cephalosporins, Cefuroxime, Loracarbef, Cefprozil, Lorabid, Cefzil, Ceftin- See Also
- Coverage
- Indications
- Respiratory tract infections
- Acute Sinusitis
- Otitis Media
- Preparations
- Loracarbef (Lorabid)
- Adult: 200 to 400 mg po bid
- Child
- Otitis Media: 30 mg/kg/day divided bid
- Other infections: 15 mg/kg/day divided bid
- Directions
- Take more than 1 hour before or 2 hours after food
- Cefprozil (Cefzil)
- Adult: 250 to 500 mg PO divided qd to bid
- Child
- Otitis Media: 15 mg/kg/dose PO bid
- Pharyngitis: 7.5 mg/kg/dose PO bid for 10 days
- Cefuroxime (Ceftin, Zinacef)
- Adult
- Parenteral: 750 to 1500 mg IM or IV every 8 hours
- Oral: 250 to 500 mg PO bid
- Child
- Parenteral: 50-100 mg/kg/day IV divided q6-8 hours
- Oral: 20-30 mg/kg/day PO divided bid
- Reported to have unpleasant taste
- Directions
- Take with food
- Adult
- Cefaclor (Ceclor)
- Listed for historical reference only
- Risk of significant serum-sickness type reaction
- Loracarbef (Lorabid)
Medication Costs | ||
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cefuroxime (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
CEFUROXIME AXETIL 250 MG TAB | Generic | $0.84 each |
CEFUROXIME AXETIL 500 MG TAB | Generic | $1.26 each |
cefprozil (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
CEFPROZIL 125 MG/5 ML SUSP | Generic | $0.24 per ml |
CEFPROZIL 250 MG TABLET | Generic | $1.01 each |
CEFPROZIL 250 MG/5 ML SUSP | Generic | $0.45 per ml |
CEFPROZIL 500 MG TABLET | Generic | $1.35 each |
ceftin (on 1/1/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
CEFTIN 125 MG/5 ML ORAL SUSP | $1.43 per ml | |
CEFTIN 250 MG/5 ML ORAL SUSP | $2.37 per ml | |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Cefuroxime (C0007562) |
|
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Definition (NCI) | A semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
Definition (MSH) | Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | D002444 |
SnomedCT | 372833007, 73986003 |
LNC | LP32648-5, MTHU027952 |
English | Cefuroxime, Cephuroxime, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, (6R-(6alpha,7beta(Z)))-, cefuroxime (medication), Cefuroxime [Chemical/Ingredient], CEFUROXIME, cephuroxime, cefuroxime, Cefuroxime (product), Cefuroxime (substance) |
Swedish | Cefuroxim |
Czech | cefuroxim |
Finnish | Kefuroksiimi |
Russian | TSEFUROKSIM, ЦЕФУРОКСИМ |
Japanese | セフロキシム |
Croatian | CEFUROKSIM |
Polish | Cefuroksym |
Spanish | cefuroxima (producto), cefuroxima (sustancia), cefuroxima, Cefuroxima |
French | Céfuroxime |
German | Cefuroxim |
Italian | Cefuroxima |
Portuguese | Cefuroxima |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
cefprozil (C0053882) |
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Definition (NCI) | A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefprozil's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefprozil inhibits bacterial septum and cell wall synthesis formation. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C052018 |
SnomedCT | 387538005, 96054007 |
LNC | LP15219-6, MTHU001907 |
English | cefprozil, CEFPROZIL, cefprozil (medication), 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-, cefprozil [Chemical/Ingredient], Cefprozil, Cefprozil (product), Cefprozil (substance) |
Spanish | cefprozilo (producto), cefprozilo, cefprozilo (sustancia), cefprozil, cefprozil (producto), cefprozil (sustancia) |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
loracarbef (C0065295) |
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Definition (NCI) | A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C054920 |
SnomedCT | 96061006, 370362008 |
LNC | LP15927-4, MTHU008099 |
English | 1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6alpha,7beta(R*)))-, loracarbef, (6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Monohydrate, loracarbef (medication), loracarbef [Chemical/Ingredient], Carbacefaclor, Loracarbef, Loracarbef (substance), Loracarbef product (product), Loracarbef product, LORACARBEF |
Spanish | loracarbef, producto con loracarbef (producto), loracarbef (producto), producto con loracarbef, carbacefaclor (sustancia), carbacefaclor |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Ceftin (C0719197) |
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Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C040738 |
English | Ceftin, ceftin |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Lorabid (C0721422) |
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Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C054920 |
English | lorabid, Lilly Brand of Loracarbef Monohydrate, Monarch Brand of Loracarbef Monohydrate, Lorabid |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Cefzil (C0728743) |
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Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C052018 |
English | Cefzil, cefzil, Bristol-Myers Squibb brand of cefprozil |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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