Infectious Disease Book

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Second Generation Anti-anaerobe Cephalosporins

Aka: Second Generation Anti-anaerobe Cephalosporins, Cefoxitin, Cefotetan, Cefamandole
  1. See Also
    1. Second Generation Broad-spectrum Cephalosporins
  2. Coverage
    1. Bacteroides
  3. Indications
    1. Abdominal Surgery prophylaxis
    2. Colorectal surgery prophylaxis
  4. Coverage
    1. Cefoxitin (Mefoxin) 1-2 grams IM or IV every 6-8 hours
    2. Cefotetan (Cefotan) 1-2 grams IM or IV every 12 hours
    3. Cefamandole
  5. Downsides
    1. Poor overall activity
    2. Expensive

Cefamandole (C0007541)

Definition (NCI) A second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole is active against Haemophilus and gram-negative bacilli susceptible to other cephalosporins. It is also active against many strains resistant to other cephalosporins, such as Enterobacter species and indole-positive Proteus species.
Definition (MSH) Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D002435
SnomedCT 372801003, 61651006
LNC LP16064-5, MTHU008441
English Cefamandole, Cephamandole, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7beta(R*)))-, cefamandole, (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic Acid, Cefamandole [Chemical/Ingredient], Cefamandole (product), Cefamandole (substance), cephamandole, CEFAMANDOLE
Swedish Cefamandol
Czech cefamandol
Finnish Kefamandoli
Russian TSEFAMANDOL, ЦЕФАМАНДОЛ
Japanese セファマンドール
Croatian CEFAMANDOL
Polish Cefamandol
Spanish cefamandol (producto), cefamandol (sustancia), cefamandol, Cefamandol
French Céfamandole
German Cefamandol
Italian Cefamandolo
Portuguese Cefamandol
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Cefotetan (C0007555)

Definition (NCI) A semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin antibiotic derived from cephalosporium. The bactericidal activity of cefotetan disodium is caused by an inhibition of bacterial cell wall synthesis via inhibition of cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Cefotetan disodium is more active against gram-negative organisms and less active against gram-positive organisms compared to first-generation cephalosporins.
Definition (MSH) A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D015313
SnomedCT 13585009, 370355004
LNC LP15066-1, MTHU001385
English Cefotetan, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7alpha))-, cefotetan (medication), Cefotetan [Chemical/Ingredient], CEFOTETAN, cefoTEtan, cefotetan, Cefotetan (substance), Cefotetan product (product), Cefotetan product
Swedish Cefotetan
Czech cefotetan
Finnish Kefotetaani
Russian TSEFOTETAN, ЦЕФОТЕТАН
Japanese セフォテタン
Spanish producto con cefotetán (producto), cefotetán (producto), producto con cefotetán, Cefotetán, cefotetán (sustancia), cefotetán
Polish Cefotetan
French Céfotétan
German Cefotetan
Italian Cefotetan
Portuguese Cefotetan
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Cefoxitin (C0007557)

Definition (NCI) A semisynthetic, broad-spectrum, second-generation cephalosporin with antibacterial activity. Cefoxitin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Definition (MSH) A semisynthetic cephamycin antibiotic resistant to beta-lactamase.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D002440
SnomedCT 372780005, 57670008
LNC LP15205-5, MTHU002759
English Cefoxitin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-methoxy-8-oxo-7-((2-thienylacetyl)amino)-, (6R-cis)-, cefoxitin (medication), Cefoxitin [Chemical/Ingredient], cefOXitin, CefOXitin, cefoxitin, CEFOXITIN, Cefoxitin (product), Cefoxitin (substance)
Swedish Cefoxitin
Czech cefoxitin
Finnish Kefoksitiini
Russian TSEFOKSITIN, ЦЕФОКСИТИН
Japanese セフォキシチン, セホキシチン
Polish Cefoksytyna
Spanish cefoxitina (producto), cefoxitina (sustancia), cefoxitina, Cefoxitina
French Céfoxitine
German Cefoxitin
Italian Cefoxitina
Portuguese Cefoxitina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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