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Second Generation Anti-anaerobe Cephalosporins
Aka: Second Generation Anti-anaerobe Cephalosporins, Cefoxitin, Cefotetan, Cefamandole- See Also
- Coverage
- Indications
- Abdominal Surgery prophylaxis
- Colorectal surgery prophylaxis
- Coverage
- Cefoxitin (Mefoxin) 1-2 grams IM or IV every 6-8 hours
- Cefotetan (Cefotan) 1-2 grams IM or IV every 12 hours
- Cefamandole
- Downsides
- Poor overall activity
- Expensive
Cefamandole (C0007541) |
|
|---|---|
| Definition (NCI) | A second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole is active against Haemophilus and gram-negative bacilli susceptible to other cephalosporins. It is also active against many strains resistant to other cephalosporins, such as Enterobacter species and indole-positive Proteus species. |
| Definition (MSH) | Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002435 |
| SnomedCT | 372801003, 61651006 |
| LNC | LP16064-5, MTHU008441 |
| English | Cefamandole, Cephamandole, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((hydroxyphenylacetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7beta(R*)))-, cefamandole, (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic Acid, Cefamandole [Chemical/Ingredient], Cefamandole (product), Cefamandole (substance), cephamandole, CEFAMANDOLE |
| Swedish | Cefamandol |
| Czech | cefamandol |
| Finnish | Kefamandoli |
| Russian | TSEFAMANDOL, ЦЕФАМАНДОЛ |
| Japanese | セファマンドール |
| Croatian | CEFAMANDOL |
| Polish | Cefamandol |
| Spanish | cefamandol (producto), cefamandol (sustancia), cefamandol, Cefamandol |
| French | Céfamandole |
| German | Cefamandol |
| Italian | Cefamandolo |
| Portuguese | Cefamandol |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Cefotetan (C0007555) |
|
|---|---|
| Definition (NCI) | A semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin antibiotic derived from cephalosporium. The bactericidal activity of cefotetan disodium is caused by an inhibition of bacterial cell wall synthesis via inhibition of cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Cefotetan disodium is more active against gram-negative organisms and less active against gram-positive organisms compared to first-generation cephalosporins. |
| Definition (MSH) | A semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative microorganisms. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D015313 |
| SnomedCT | 13585009, 370355004 |
| LNC | LP15066-1, MTHU001385 |
| English | Cefotetan, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7alpha))-, cefotetan (medication), Cefotetan [Chemical/Ingredient], CEFOTETAN, cefoTEtan, cefotetan, Cefotetan (substance), Cefotetan product (product), Cefotetan product |
| Swedish | Cefotetan |
| Czech | cefotetan |
| Finnish | Kefotetaani |
| Russian | TSEFOTETAN, ЦЕФОТЕТАН |
| Japanese | セフォテタン |
| Spanish | producto con cefotetán (producto), cefotetán (producto), producto con cefotetán, Cefotetán, cefotetán (sustancia), cefotetán |
| Polish | Cefotetan |
| French | Céfotétan |
| German | Cefotetan |
| Italian | Cefotetan |
| Portuguese | Cefotetan |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Cefoxitin (C0007557) |
|
|---|---|
| Definition (NCI) | A semisynthetic, broad-spectrum, second-generation cephalosporin with antibacterial activity. Cefoxitin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
| Definition (MSH) | A semisynthetic cephamycin antibiotic resistant to beta-lactamase. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002440 |
| SnomedCT | 372780005, 57670008 |
| LNC | LP15205-5, MTHU002759 |
| English | Cefoxitin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-methoxy-8-oxo-7-((2-thienylacetyl)amino)-, (6R-cis)-, cefoxitin (medication), Cefoxitin [Chemical/Ingredient], cefOXitin, CefOXitin, cefoxitin, CEFOXITIN, Cefoxitin (product), Cefoxitin (substance) |
| Swedish | Cefoxitin |
| Czech | cefoxitin |
| Finnish | Kefoksitiini |
| Russian | TSEFOKSITIN, ЦЕФОКСИТИН |
| Japanese | セフォキシチン, セホキシチン |
| Polish | Cefoksytyna |
| Spanish | cefoxitina (producto), cefoxitina (sustancia), cefoxitina, Cefoxitina |
| French | Céfoxitine |
| German | Cefoxitin |
| Italian | Cefoxitina |
| Portuguese | Cefoxitina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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