Infectious Disease Book

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Quinupristin-Dalfopristin

Aka: Quinupristin-Dalfopristin, Synercid, Streptogramin
  1. Indications: Severe Gram Positive Infections
    1. Vancomycin-resistant Enterococcus
    2. Methicillin susceptible Staphylococcus aureus
    3. Methicillin susceptible Streptococcus Pyogenes
  2. Mechanism
    1. Bacterial 50S Ribosome
    2. Resistance rare
  3. Pharmacokinetics
    1. Hepatic clearance predominates
    2. Half-life: 1-3 hours (9-10 hours of affect)
  4. Adverse Effects
    1. Arthralgias or myalgias
    2. Nausea, Diarrhea or Vomiting
    3. Rash or Pruritus
    4. Headache
  5. Drug Interactions: Metabolized by Cytochrome P-450 3A4
    1. Raises serum drug levels of substrates in 3A4 system
    2. Follow Cyclosporine levels when using concurrently
  6. Dosing
    1. Enterococcus faecium: 7.5 mg/kg IV q8 hours
    2. Severe Skin Infections: 7.5 mg/kg IV q12 hours
  7. References
    1. Allington (2001) Clin Ther 23(1):24-44 [PubMed]
    2. Lamb (1999) Drugs 58(6):1061-97 [PubMed]
    3. Lundstrom (2000) Infect Dis Clin North Am 14(2):463-74 [PubMed]
    4. Manzella (2001) Am Fam Physician 64(11):1863-6 [PubMed]
    5. Paradisi (2001) Med Clin North Am 85(1):1-17 [PubMed]

Streptogramins (C0205997)

Definition (MSH) A class of natural cyclic peptide antibiotics produced by certain subspecies of STREPTOMYCES. They include two structurally unrelated components, STREPTOGRAMIN GROUP A and STREPTOGRAMIN GROUP B, which generally act synergistically to inhibit bacterial growth.
Concepts Antibiotic (T195) , Amino Acid, Peptide, or Protein (T116)
MSH D025361
SnomedCT 420946006, 422292008
English Streptogramins, Streptogramin, Streptogramin (product), Streptogramin (substance), Streptogramins [Chemical/Ingredient], streptogramin, streptogramins
Spanish estreptogramina (producto), estreptogramina (sustancia), estreptogramina, Estreptograminas
Swedish Streptograminer
Czech streptograminy
Finnish Streptogramiinit
French Streptogramine, Streptogramines, Synergystines
Russian STREPTOGRAMINY, СТРЕПТОГРАМИНЫ
Japanese ストレプトグラミン
Italian Steptogramina, Steptogramine
Polish Streptograminy
German Streptogramine
Portuguese Estreptograminas
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Synercid (C0526512)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C062940
English Synercid, synercid
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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