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Quinupristin-Dalfopristin
Aka: Quinupristin-Dalfopristin, Synercid, Streptogramin- Indications: Severe Gram Positive Infections
- Vancomycin-resistant Enterococcus
- Methicillin susceptible Staphylococcus aureus
- Methicillin susceptible Streptococcus Pyogenes
- Mechanism
- Bacterial 50S Ribosome
- Resistance rare
- Pharmacokinetics
- Hepatic clearance predominates
- Half-life: 1-3 hours (9-10 hours of affect)
- Adverse Effects
-
Drug Interactions: Metabolized by Cytochrome P-450 3A4
- Raises serum drug levels of substrates in 3A4 system
- Follow Cyclosporine levels when using concurrently
- Dosing
- Enterococcus faecium: 7.5 mg/kg IV q8 hours
- Severe Skin Infections: 7.5 mg/kg IV q12 hours
- References