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Penicillinase-Resistant Penicillin
Aka: Penicillinase-Resistant Penicillin, Penicillinase-Resistant Semisynthetic Penicillin, Cloxacillin, Dicloxacillin, Methicillin, Nafcillin, Oxacillin- See Also
- Indications
- Staphylococcus Infection
- Staphylococcus aureus
- Staphylococcus epidermidis
- Specific Infections
- Skin Infection
- Soft tissue infection
- Lymphatic infection
- Bone Infection
- Joint infection
- Staphylococcus Infection
- Mechanism
- Same action to Natural Penicillins
- Prevents Penicillinase hydrolysis of Beta lactam ring
- Mechanism: Bacterial Resistance mechanisms
- Alteration of Bacterial cell wall
- Mechanism: Activity Spectrum
- Same as for Natural Penicillins
- Preparations: Oral
- Directions
- Take on an empty Stomach
- Take more than 1 hour before or two hours after food
- Cloxacillin (Cloxapen) 250-500 mg PO qid
- Dicloxacillin (Dynapen)
- Adult: 125 to 500 mg PO qid
- Child: 12.5 to 25 mg/kg/day PO divided qid
- Directions
- Preparations: Parenteral
- Methicillin (Staphcillin)
- Nafcillin (Nafcil, Unipen)
- Adult: 1 to 2 grams IM or IV every 4 hours
- Child: 50 to 200 mg/kg/day divided every 4 to 6 hours
- Oxacillin (Bactocill)
- Adult: 1 to 2 grams IM or IV every 4 to 6 hours
- Adverse effects
- Nephritis (Methicillin)
- Venous inflammation (Nafcillin)
| Medication Costs | ||
|---|---|---|
| dicloxacillin (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| DICLOXACILLIN 250 MG CAPSULE | Generic | $0.50 each |
| DICLOXACILLIN 500 MG CAPSULE | Generic | $0.80 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Cloxacillin (C0009077) |
|
|---|---|
| Definition (NCI) | A semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis. |
| Definition (MSH) | A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D003023 |
| SnomedCT | 373276005, 68422006 |
| LNC | LP15442-4, MTHU006903 |
| English | Chloroxacillin, Cloxacillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, cloxacillin, Cloxacillin [Chemical/Ingredient], CLOXACILLIN, Cloxacillin (product), Cloxacillin (substance) |
| Swedish | Kloxacillin |
| Czech | kloxacilin |
| Finnish | Kloksasilliini |
| Russian | NATRIIA KLOKSATSILLIN, KLOKSATSILLIN, KHLOROKSATSILLIN, КЛОКСАЦИЛЛИН, НАТРИЯ КЛОКСАЦИЛЛИН, ХЛОРОКСАЦИЛЛИН |
| Japanese | クロキサシリンナトリウム, クロロキサシリン, クロキサシリン, ソジウムクロキサシリン |
| Italian | Cloro oxacillina, Cloxacillina |
| Croatian | KLOKSACILIN |
| Polish | Syntarpen, Kloksacylina |
| Spanish | cloxacilina (producto), cloxacilina (sustancia), cloxacilina, Cloroxacilina, Cloxacilina |
| French | Cloxacilline |
| German | Chloroxacillin, Cloxacillin |
| Portuguese | Cloroxacilina, Cloxacilina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Dicloxacillin (C0012093) |
|
|---|---|
| Definition (NCI) | A broad-spectrum, semi-synthetic, beta-lactam, penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Dicloxacillin binds to penicillin binding proteins (PBP) located on the inner membrane of the bacterial cell wall. It also inhibits the cross-linkage of peptidoglycan, a critical component of bacterial cell walls. This leads to the inhibition of bacterial cell wall synthesis and eventually causes cell lysis. |
| Definition (MSH) | One of the PENICILLINS which is resistant to PENICILLINASE. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D004009 |
| SnomedCT | 372873001, 8416000 |
| LNC | LP14990-3, MTHU002293 |
| English | Dichloroxacillin, Dicloxaciclin, Dicloxacillin, Dicloxacycline, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolylpenicillin, dicloxacillin, Dicloxacillin [Chemical/Ingredient], dicloxacillin (medication), DICLOXACILLIN, Dicloxacillin (product), Dicloxacillin (substance) |
| Swedish | Dikloxacillin |
| Czech | dikloxacilin |
| Finnish | Dikloksasilliini |
| Russian | DIKHLOROKSATSILLIN, DIKLOKSATSILLIN, ДИКЛОКСАЦИЛЛИН, ДИХЛОРОКСАЦИЛЛИН |
| Japanese | ジクロキサシリン, ジクロロキサシリン, ジクロキサシリンナトリウム |
| Italian | Dicloxacilina, Dicloxaciclina, Dicloxacillina |
| Polish | Dikloksacylina |
| Spanish | dicloxacilina (producto), dicloxacilina (sustancia), dicloxacilina, Dicloroxacilina, Dicloxacilina |
| French | Dicloxacilline |
| German | Dichloroxacillin, Dicloxacillin |
| Portuguese | Dicloroxacilina, Dicloxacilina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Methicillin (C0025643) |
|
|---|---|
| Definition (NCI) | A semisynthetic, narrow spectrum beta-lactamase-resistant penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Methicillin binds to specific penicillin-binding proteins (BPBs) on the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial lysis. |
| Definition (MSH) | One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. |
| Definition (CSP) | semisynthetic penicillin used as an antibacterial in resistant staphylococcal infections. |
| Concepts | Organic Chemical (T109) , Antibiotic (T195) |
| MSH | D008712 |
| SnomedCT | 373515001, 61862008 |
| LNC | LP15975-3, MTHU008454 |
| English | Dimethoxyphenyl Penicillin, Methicillin, Penicillin, Dimethoxyphenyl, methicillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((2,6-dimethoxybenzoyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, Meticillin, 2,6 dimethoxyphenylpenicillin, Methicillin [Chemical/Ingredient], meticillin, Methicillin (product), Methicillin (substance), METHICILLIN |
| Swedish | Meticillin |
| Czech | methicilin |
| Finnish | Metisilliini |
| Russian | METITSILLIN, PENITSILLIN, DIMETOKSIFENIL, МЕТИЦИЛЛИН, ПЕНИЦИЛЛИН, ДИМЕТОКСИФЕНИЛ |
| Japanese | ジメトキシフェニルペニシリン, メチシリン, メチシリンナトリウム |
| Italian | Dimetossifenil-penicillina, Meticillina |
| Croatian | METICILIN |
| Polish | Penicylina dwumetoksyfenylowa, Metycylina |
| Spanish | meticilina (producto), meticilina (sustancia), meticilina, Dimetoxifenil Penicilina, Meticilina |
| French | Méticilline |
| German | Methicillin, Penicillin, Dimethoxyphenyl- |
| Portuguese | Dimetoxifenil Penicilina, Meticilina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Nafcillin (C0027324) |
|
|---|---|
| Definition (NCI) | A semi-synthetic naphthalene and beta-lactam antibiotic with antibacterial activity. Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci. (NCI04) |
| Definition (MSH) | A semi-synthetic antibiotic related to penicillin. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D009254 |
| SnomedCT | 372898000, 91169009 |
| LNC | LP14999-4, MTHU002302 |
| English | Nafcillin, Naphthamidopenicillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2-ethoxy-1-naphthalenyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, Nafcillin [Chemical/Ingredient], nafcillin (medication), nafcillin, NAFCILLIN, Nafcillin (product), Nafcillin (substance) |
| Swedish | Nafcillin |
| Czech | nafcilin |
| Finnish | Nafsilliini |
| Russian | NAFTAMIDOPENITSILLIN, NATRIIA NAFTSILLIN, NAFTSILLIN, НАТРИЯ НАФЦИЛЛИН, НАФТАМИДОПЕНИЦИЛЛИН, НАФЦИЛЛИН |
| Japanese | ナフシリンナトリウム, ナフタミドペニシリン, ソジウムナフシリン, ナフシリン |
| Polish | Nafcylina |
| Spanish | nafcilina (producto), nafcilina (sustancia), nafcilina, Nafcilina, Naftamidopenicilina |
| French | Nafcilline |
| German | Nafcillin, Naphthamidopenicillin |
| Italian | Nafcillina |
| Portuguese | Nafcilina, Naftamidopenicilina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Oxacillin (C0029983) |
|
|---|---|
| Definition (NCI) | A semisynthetic penicillinase-resistant and acid-stable penicillin with an antimicrobial activity. Oxacillin binds to penicillin-binding proteins in the bacterial cell wall, thereby blocking the synthesis of peptidoglycan, a critical component of the bacterial cell wall. This leads to inhibition of cell growth and causes cell lysis. |
| Definition (MSH) | An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D010068 |
| SnomedCT | 372868007, 83201006, 85724000 |
| LNC | LP16206-2, MTHU008465 |
| English | Methylphenylisoxazolyl Penicillin, Oxacillin, Oxazocilline, Penicillin, Methylphenylisoxazolyl, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((5-methyl-3-phenyl-4-isoxazolyl)carbonyl)amino)-7-oxo-, (2S-(2alpha,5alpha,6beta))-, Oxacillin [Chemical/Ingredient], oxacillin (medication), oxacillin, OXACILLIN, Methylphenyl isoxazolyl penicillin, Oxacillin (product), Oxacillin (substance) |
| Swedish | Oxacillin |
| Czech | oxacilin |
| Finnish | Oksasilliini |
| Russian | OKSATSILLIN, NATRIIA OKSATSILLIN, OKSAZOTSILLIN, PENITSILLIN, METILFENILIZOKSAZOLIL, НАТРИЯ ОКСАЦИЛЛИН, ОКСАЗОЦИЛЛИН, ОКСАЦИЛЛИН, ПЕНИЦИЛЛИН, МЕТИЛФЕНИЛИЗОКСАЗОЛИЛ |
| Japanese | オキサゾシリン, メチルフェニルイソキサゾリルペニシリン, オキサシリン, ペニシリン-メチルフェニルイソキサゾリル, ソジウムオキサシリン, オキサシリンナトリウム |
| Croatian | Not Translated[Oxacillin] |
| Polish | Oksacylina, Penicylina metylfenyloksazolowa |
| Spanish | metilfenil isoxazolil penicilina, oxacilina (producto), oxacilina (sustancia), oxacilina, Metilfenilisoxazolil Penicilina, Oxacilina, Oxazocilina |
| French | Oxacilline |
| German | Oxacillin, Oxazocillin, Penicillin, Methylphenylisoxazolyl- |
| Italian | Oxacillina |
| Portuguese | Metilfenilisoxazolil Penicilina, Oxacilina, Oxazocilina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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