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Metronidazole
Aka: Metronidazole, Flagyl- Indications
- Protozoal Infection
- Anaerobic Bacteria infection
- Precautions
- Carcinogenic in mice and rats (FDA Black box warning)
- Pharmacokinetics
- Half-life: 8 hours
- Renal excretion
- Dosing: Children
- Dose
- Load: Metronidazole 15 mg/kg IV
- Maintenance: Metronidazole 7.5 mg/kg/dose
- Interval
- First week of life: q12 hours
- After first week of life: q 8hours
- Dose
- Dosing: Adult
- Intravenous
- Loading dose: 15 mg/kg up to 1000 mg IV
- Maintenance dose: 7.5 mg/kg up to 500 mg IV q6-8 hour
- Oral dose: 250 to 750 mg PO tid
- Intravenous
- Adverse Effects
- Antabuse like effect (Never use with Alcohol)
- Gastrointestinal intolerance
- Neurotoxicity (stop immediately if these occur)
- Seizures
- Encephalopathy
- Cerebellar dysfunction
- Peripheral Neuropathy (e.g. distal Paresthesias)
- Pregnancy
- Class B Medication (Avoid in first trimester pregnancy)
- Directions
- Taking with food decreases gastric irritation
- References
| Medication Costs | ||
|---|---|---|
| metronidazole (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| METRONIDAZOLE 0.75% CREAM | Generic | $1.68 per gram |
| METRONIDAZOLE 0.75% LOTION | Generic | $2.73 per ml |
| METRONIDAZOLE 250 MG TABLET | Generic | $0.22 each |
| METRONIDAZOLE 500 MG TABLET | Generic | $0.34 each |
| METRONIDAZOLE TOP 1% GEL PUMP | Generic | $3.21 per gram |
| METRONIDAZOLE TOPICAL 0.75% GL | Generic | $1.72 per gram |
| METRONIDAZOLE TOPICAL 1% GEL | Generic | $3.09 per gram |
| METRONIDAZOLE VAGINAL 0.75% GL | Generic | $1.02 per gram |
| flagyl (on 6/1/2016 at Medicaid.Gov Pharmacy Drug pricing) | ||
| FLAGYL ER 750 MG TABLET | $22.02 each | |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Metronidazole (C0025872) |
|
|---|---|
| Definition (CHV) | a drug that treats bacterial and fungal infection |
| Definition (CHV) | a drug that treats bacterial and fungal infection |
| Definition (NCI) | A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
| Definition (NCI_NCI-GLOSS) | A drug that is used to treat infection and is being studied in the treatment of cancer. It is a type of antibacterial, antiprotozoal, and anthelmintic. |
| Definition (MSH) | A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed). |
| Definition (CSP) | antiprotozoal and antibacterial effective against obligate anaerobes. |
| Definition (PDQ) | A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C651" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D008795 |
| SnomedCT | 326285001, 332974000, 1222004, 372602008 |
| LNC | LP14997-8, MTHU002300 |
| English | 1H-Imidazole-1-ethanol, 2-methyl-5-nitro-, Metronidazole [skin], 2 Methyl 5 nitroimidazole 1 ethanol, 2-Methyl-5-nitroimidazole-1-ethanol, Metronidazole, metronidazole, Metronidazole [vaginal], METRONIDAZOLE, metronidazole (medication), Metronidazole [Chemical/Ingredient], metronidazole vaginal, metroNIDAZOLE, MetroNIDAZOLE, Metronidazole [vaginal] (product), Metronidazole [skin] (product), Metronidazole product, Metronidazole (product), Metronidazole (substance), METRO, Metronidazole [skin] (substance), Metronidazole [vaginal] (substance) |
| Swedish | Metronidazol |
| Czech | metronidazol |
| Finnish | Metronidatsoli |
| Russian | METRONIDAZOL, МЕТРОНИДАЗОЛ |
| Japanese | フラジール, フラギル, 安息香酸メトロニダゾール, クロント, ダニゾール, メトロニダゾールホスファート, 塩酸メトロニダゾール, メトロニダゾール塩酸塩, メトロニダゾールベンゾアート, アスゾール, メトロニダゾール, メトロニダゾールリン酸, トリカゾール, ギネフラビル, トリバゾール |
| Polish | Metronidazol |
| Norwegian | Metronidazol |
| Croatian | Metronidazol |
| Spanish | metronidazol [uso vaginal], metronidazol (uso dermatológico) (producto), metronidazol [uso vaginal] (producto), metronidazol (uso dermatológico), metronidazol (piel) (producto), metronidazol (piel), metronidazol (producto), metronidazol (sustancia), metronidazol, Metronidazol |
| French | Métronidazole |
| German | Metronidazol |
| Italian | Metronidazolo |
| Portuguese | Metronidazol |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Flagyl (C0699678) |
|
|---|---|
| Definition (CHV) | brand name of an antibiotic |
| Definition (CHV) | brand name of an antibiotic |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D008795 |
| English | flagyl, flagyl [brand name], Flagyl |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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