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Ketoconazole
Aka: Ketoconazole, Nizoral- See Also
- Imidazole
- Topical Antifungal
- Precautions
- Hepatotoxicity risk (FDA black box warning)
- Oral forumulation indicated only for severe, refractory systemic fungal infections due to Ketoconazole hepatotoxicity
- No longer indicated in Skin Infections
- If Ketoconazole is used, requires Liver Function Tests at baseline and again weekly
- Hepatotoxicity risk (FDA black box warning)
- Adverse Effects: Oral (systemic formulation)
- Nausea
- Headache
- Liver toxicity (Hepatotoxicity)
- Adrenal Insufficiency
- Hyperkalemia
-
Drug Interactions: Oral (systemic formulation)
- Serious Cardiac Arrhythmia with Hismanal or Seldane (off market in U.S.)
- Multiple other Drug Interactions
- CYP2C9 Inhibitor
- CYP3A3 Inhibitor and CYP3A4 Inhibitor
- Lab monitoring: Oral (systemic formulation)
- Follow Liver Function Tests at baseline and weekly
- Directions
- Taking with food decreases gastric irritation
Medication Costs | ||
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ketoconazole (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
KETOCONAZOLE 2% CREAM | Generic | $1.12 per gram |
KETOCONAZOLE 2% SHAMPOO | Generic | $0.07 per ml |
KETOCONAZOLE 200 MG TABLET | Generic | $1.49 each |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Ketoconazole (C0022625) |
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Definition (NCI_NCI-GLOSS) | A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones. |
Definition (NCI) | A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04) |
Definition (MSH) | Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. |
Definition (CSP) | 1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal. |
Definition (PDQ) | A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39488&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C605" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D007654 |
SnomedCT | 326240002, 332902002, 324673001, 387216007, 40232005 |
LNC | LP15862-3, MTHU002299 |
English | Ketoconazole, Piperazine, 1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-, cis-, Ketoconazole [gyn], Ketoconazole [infections], Ketoconazole [skin], Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, ketoconazole, Ketoconazole [gynaecological use], Ketoconazole [gynecological use], ketoconazole (medication), KETOCONAZOLE, Ketoconazole [Chemical/Ingredient], Ketoconazole [skin] (product), Ketoconazole [infections] (product), Ketoconazole [gynecological use] (product), Ketoconazole (product), Ketoconazole (substance), KCZ, Ketoconazole [gynecological use] (substance), Ketoconazole [infections] (substance), Ketoconazole [skin] (substance) |
Swedish | Ketokonazol |
Spanish | ketoconazol [infecciones], ketoconazol (piel), Cetoconazol, cetoconazol (uso dermatológico), ketoconazol [antiinfeccioso], ketoconazol [antiinfeccioso] (producto), ketoconazol (uso dermatológico) (producto), cetoconazol [uso ginecológico], ketoconazol (uso dermatológico), cetoconazol (uso dermatológico) (producto), ketoconazol [uso ginecológico] (producto), ketoconazol [uso ginecológico], cetoconazol [antiinfeccioso], Ketoconazol, cetoconazol (producto), cetoconazol (sustancia), cetoconazol, ketoconazol (piel) (producto), ketoconazol (producto), ketoconazol (sustancia), ketoconazol [infecciones] (producto), ketoconazol |
Czech | ketokonazol |
Finnish | Ketokonatsoli |
Russian | KETOKONAZOL, КЕТОКОНАЗОЛ |
Japanese | ケトコナゾール, ニゾラール, ニトラゼン, ケトパミン, プルナ |
Croatian | KETOKONAZOL |
Polish | Ketokonazol |
Portuguese | Cetoconazol, Ketoconazol |
French | Kétoconazole |
German | Ketoconazol |
Italian | Ketoconazolo |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Nizoral (C0699439) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D007654 |
English | Janssen Brand of Ketoconazole, Ketoconazole Janssen Brand, nizoral, Nizoral |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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