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First Generation Cephalosporins
Aka: First Generation Cephalosporins, Cephalexin, Cefazolin, Cefadroxil, Keflex, Duricef, Ancef- Indications
- Effective alternative to Penicillins
- Covers Gram Positive Cocci
- Clinical Conditions
- Skin and Soft Tissue Infection
- Streptococcal Pharyngitis
- Not indicated for Otitis Media
- Mechanism: Activity Spectrum
- Good Gram Positive Cocci Coverage
- Modest EKP Gram Negative Bacteria covered
- Preparations: Oral
- Directions
- May take with or without food
- Cephalexin (Keflex)
- Adult: 250 to 500 mg PO qid
- Child
- Otitis Media: 75 to 100 mg/kg/day divided qid
- Standard Dose: 25 to 50 mg/kg/day divided qid
- Cefadroxil (Duricef)
- Adult: 1 to 2 grams/day divided qd to bid
- Child: 30 mg/kg/day divided bid
- Directions
- Parenteral: Cefazolin (Ancef)
- Adult: 0.5 to 1.5 grams IM or IV every 6-8 hours
- Child
- Standard: 25 to 50 mg/kg/day divided q6-8 hours
- Severe Infection: 100 mg/kg/day divided q6-8 hours
- Maximum: 2 grams per dose
| Medication Costs | ||
|---|---|---|
| Cephalexin (on 6/18/2017 at Walmart.com) | ||
| Cephalexin 250mg | #28 capsules for $4.00 | $0.14 each |
| Cephalexin 250mg | #84 capsules for $10.00 | $0.12 each |
| Cephalexin 500mg | #30 capsules for $4.00 | $0.13 each |
| Cephalexin 500mg | #90 capsules for $10.00 | $0.11 each |
| cephalexin (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CEPHALEXIN 125 MG/5 ML SUSP | Generic | $0.14 per ml |
| CEPHALEXIN 250 MG CAPSULE | Generic | $0.08 each |
| CEPHALEXIN 250 MG/5 ML SUSP | Generic | $0.15 per ml |
| CEPHALEXIN 500 MG CAPSULE | Generic | $0.08 each |
| cefadroxil (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CEFADROXIL 250 MG/5 ML SUSP | Generic | $0.29 per ml |
| CEFADROXIL 500 MG CAPSULE | Generic | $0.25 each |
| CEFADROXIL 500 MG/5 ML SUSP | Generic | $0.35 per ml |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Cefadroxil (C0007538) |
|
|---|---|
| Definition (NCI) | A semi-synthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cefadroxil binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
| Definition (MSH) | Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002434 |
| SnomedCT | 13414000, 372651006 |
| LNC | LP17101-4, MTHU005578 |
| English | 4 Hydroxycephalexin, 4-Hydroxycephalexin, Cefadroxil, Cephadroxyl, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-, (6R,7R)-7-(((2R)-Amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, cefadroxil, CEFADROXIL, Cefadroxil [Chemical/Ingredient], cephadroxyl, Cefadroxil Monohydrate, Cefadroxil (product), Cefadroxil (substance) |
| Swedish | Cefadroxil |
| Czech | cefadroxil |
| Finnish | Kefadroksiili |
| Italian | 4-Idrossi cefalessina, Cefadrossil |
| Russian | TSEFADROKSIL, ЦЕФАДРОКСИЛ |
| Japanese | セファドロキシル |
| Polish | Cefadroksyl |
| Spanish | cefadroxilo (producto), cefadroxilo (sustancia), cefadroxilo, Cefadroxilo |
| French | Céfadroxil |
| German | Cefadroxil |
| Portuguese | Cefadroxila |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Cefazolin (C0007546) |
|
|---|---|
| Definition (NCI) | A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
| Definition (MSH) | A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002437 |
| SnomedCT | 323932006, 81088002, 387470007 |
| LNC | LP16066-0, MTHU005579 |
| English | Cefazolin, Cephazolin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-, (6R-trans)-, (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Cefazolin [Chemical/Ingredient], cephazolin, ceFAZolin, CEFAZOLIN, cefazolin, Cephazolin (product), Cephazolin (substance) |
| Swedish | Cefazolin |
| Czech | cefazolin |
| Finnish | Kefatsoliini |
| Russian | TSEFAZOLIN, ЦЕФАЗОЛИН |
| Japanese | セファゾリン, セファゾリンナトリウム |
| Polish | Cefazolina |
| Spanish | cefazolina (producto), cefazolina (sustancia), cefazolina, Cefazolina |
| French | Céfazoline |
| German | Cefazolin, Cephazolin |
| Italian | Cefazolina |
| Portuguese | Cefazolina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Cephalexin (C0007716) |
|
|---|---|
| Definition (CHV) | an antibiotic drug |
| Definition (CHV) | an antibiotic drug |
| Definition (NCI) | A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms. |
| Definition (NCI_NCI-GLOSS) | An antibiotic drug that belongs to the family of drugs called cephalosporins. |
| Definition (MSH) | A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. |
| Definition (PDQ) | A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to second and third generation cephalosporins, cephalexin is more active against gram-positive and less active against gram-negative organisms. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43417&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43417&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C356" NCI Thesaurus) |
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002506 |
| SnomedCT | 54887004, 387304003 |
| LNC | LP15264-2, MTHU005030 |
| English | Cefalexin, Cephalexin, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-, cephalexin, cephalexin (medication), CEPHALEXIN, Cephalexin [Chemical/Ingredient], cefalexin, Cephalexin (product), Cephalexin (substance) |
| Swedish | Cefalexin |
| Czech | cefalexin |
| Finnish | Kefaleksiini |
| German | Cefalexin, Cephalexin |
| Russian | TSEFALEKSIN, ЦЕФАЛЕКСИН |
| Japanese | セファレキシン |
| Croatian | CEFALEKSIN |
| Polish | Cefaleksyna |
| Spanish | cefalexina (producto), cefalexina (sustancia), cefalexina, Cefalexina |
| French | Céfalexine |
| Italian | Cefalexina |
| Portuguese | Cefalexina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Keflex (C0700517) |
|
|---|---|
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| English | Keflex, keflex |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Ancef (C0700926) |
|
|---|---|
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002437 |
| English | ancef, Ancef |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Duricef (C0701890) |
|
|---|---|
| Concepts | Antibiotic (T195) , Organic Chemical (T109) |
| MSH | D002434 |
| English | duricef, Duricef |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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