Infectious Disease Book


Drug-Induced Fever

Aka: Drug-Induced Fever, Drug Induced Fever, Fever Due to Medications, Drug Fever, Drug-Induced Hyperpyrexia
  1. See Also
    1. Fever
    2. Fever of Unknown Origin
    3. Fever of Unknown Origin History
    4. Drug-Induced Fever
    5. Fever of Unknown Origin Causes
    6. Fever of Unknown Origin Causes by Age
    7. Fever in the Returning Traveler
    8. Fever of Unknown Origin Causes in Comorbid Conditions
    9. Fever of Unknown Origin History
  2. Types
    1. Hypersensitivity Reaction (associated with Eosinophilia, rash)
    2. Idiosyncratic Reaction
    3. Drug-Induced Hyperthemia Syndromes (Muscle rigidity and fever >40 C)
      1. Malignant Hyperthermia
      2. Neuroleptic Malignant Syndrome
      3. Serotonin Syndrome
  3. Signs: Intensive Care Unit Patients
    1. Rigors (53%)
    2. Myalgias (25%)
    3. Leukocytosis (22%)
    4. Eosinophilia (22%)
    5. Rash (18%)
    6. Hypotension (18%)
  4. Causes: Antimicrobial Induced Fever
    1. Amphotericin
    2. Carbapenems
    3. Cephalosporins (common)
    4. Erythromycin
    5. Isoniazid
    6. Minocycline
    7. Penicillins (common)
    8. Nitrofurantoin
    9. Rifampin
    10. Sulfonamides
    11. Vancomycin
  5. Causes: Cardiovascular Medication Induced Fever
    1. Atropine
    2. Captopril
    3. Clofibrate
    4. Hydralazine
    5. Hydrochlorothiazide
    6. Methyldopa
    7. Nifedipine
    8. Procainamide (common)
    9. Quinidine (common)
    10. Streptokinase
  6. Causes: Anticonvulsant induced fever
    1. Barbiturates
    2. Carbamazepine (Tegretol)
    3. Phenytoin or Dilantin (common)
  7. Causes: Gastrointestinal Medication induced fever
    1. Cimetidine (Tagemet)
    2. Ranitidine (Zantac)
    3. Phenothiazines
  8. Causes: Analgesics
    1. Aspirin
    2. Ibuprofen
    3. Sulindac (Clinoril)
    4. Meperidine (Demerol)
  9. Causes: Miscellaneous Medications Inducing Fever
    1. Allopurinol
    2. Heparin
  10. Management
    1. Withdraw suspected medication causes
      1. Expect fever to resolve within 2-3 days (up to 7 days) of medication discontinuation
    2. Exclude other sources of fever
      1. See Acquired Fever in Hospitalized Patients
      2. See Persistent Fever Causes
  11. References
    1. Marino (2014) The ICU Book, p. 777-95
    2. Hersch (2014) Am Fam Physician 90(2): 91-6 [PubMed]
    3. Johnson (1996) Infect Dis Clin North Am 10(1): 85-91 [PubMed]

Drug-induced hyperpyrexia (C1320835)

Concepts Pathologic Function (T046)
SnomedCT 95908009, 405543000
English DRUG FEVER, drug fever, drug fever (diagnosis), drug fevers, fever drug, drugs fever, Drug fever, Drug fever (finding), Drug-induced hyperpyrexia (finding), Drug-induced hyperpyrexia
Dutch geneesmiddelkoorts
French Fièvre d'origine médicamenteuse, FIEVRE D'ORIGINE MEDICAMENTEUSE
German von Medikamenten ausgeloestes Fieber, ARZNEIMITTELFIEBER
Italian Febbre da farmaci
Portuguese Febre por efeito de fármaco, FEBRE DE CAUSA MEDICAMENTOSA
Spanish Fiebre medicamentosa, FIEBRE MEDICAMENTOSA, fiebre farmacógena, fiebre medicamentosa (hallazgo), fiebre medicamentosa, hiperpirexia medicamentosa (hallazgo), hiperpirexia medicamentosa
Japanese 薬物性発熱, ヤクブツセイハツネツ
Czech Léková horečka
Hungarian Gyógyszer okozta láz
Derived from the NIH UMLS (Unified Medical Language System)

Drug induced fever (C2830448)

Concepts Pathologic Function (T046)
ICD10 R50.2
English Drug induced fever
Derived from the NIH UMLS (Unified Medical Language System)

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