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Chloroquine
Aka: Chloroquine, Aralen- Indications: Malaria Prophylaxis
- Areas without Chloroquine resistance
- Safety
- Safe in all trimesters of pregnancy
- Safe for children of all ages
- Dose: Prophylaxis
- Protocol
- Start 1-2 weeks before travel
- Continue through 4 weeks after return
- Adult: 300 mg base (500 mg salt) PO once weekly
- Child: Dose: 5 mg/kg base (8.3 mg/kg salt) up to 300 mg base orally once weekly
- Protocol
- Directions
- Taking with food decreases gastric irritation
- Adverse Effects
- Efficacy
- Most world regions exhibit high Chloroquine resistance in Plasmodium Falciparum
| Medication Costs | ||
|---|---|---|
| chloroquine (on 8/17/2016 at Medicaid.Gov Pharmacy Drug pricing) | ||
| CHLOROQUINE PH 500 MG TABLET | Generic | $11.13 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Chloroquine (C0008269) |
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|---|---|
| Definition (NCI) | A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. |
| Definition (MSH) | The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. |
| Definition (CSP) | antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D002738 |
| SnomedCT | 330034001, 324890009, 14728000, 373468005 |
| LNC | LP16070-2, MTHU014870 |
| English | Chingamin, Chlorochin, Chloroquine, Khingamin, chloroquine, 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, Chloroquine [anti-malarial], Chloroquine [musculo-skeletal], chloroquine (medication), Chloroquine [Chemical/Ingredient], chloroquine products, Chloroquine [musculo-skeletal] (product), Chloroquine [anti-malarial] (product), CHLOROQUINE, Chloroquine (product), Chloroquine (substance), Chloroquine [anti-malarial] (substance), Chloroquine [musculo-skeletal] (substance) |
| Swedish | Klorokin |
| Czech | chlorochin, chloroquin |
| Finnish | Klorokiini |
| Russian | KHLOROKHIN, KHINGAMIN, ХИНГАМИН, ХЛОРОХИН |
| Japanese | リン酸クロロキン, クロロキン |
| Polish | Arechina, Resochina, Chlorochina |
| Spanish | cloroquina [antipalúdico] (producto), cloroquina [uso musculoesquelético] (producto), cloroquina [antipalúdico], cloroquina [uso musculoesquelético], cloroquina (producto), cloroquina (sustancia), cloroquina, Cloroquina |
| Croatian | Klorokin |
| French | Chloroquine |
| German | Chlorochin |
| Italian | Clorochina |
| Portuguese | Cloroquina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Aralen Phosphate (C0718643) |
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|---|---|
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| English | Aralen Phosphate |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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