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Immunoglobulin G
Aka: Immunoglobulin G, IgG Immunoglobulin, Gamma Globulin G, IgG
- Lab: Normal
- Range: 800-1500 mg/dl
- Varies by age
- Physiology
- Structure
- Accounts for 75% of all Antibody
- Subclasses IgG1, IgG2, IgG3, IgG4
- Monomer with Molecular weight 160,000 dalton
- Serum half-life of 23 days
- Function
- Responsible for long lasting Immunity (secondary immune response) and Type 2 Hypersensitivity
- Crosses maternal-fetal membrane
- Interacts with complement system
- Enhances Phagocytosis by binding Macrophages and PMNs
- Enhance cytotoxicity by binding Natural Killer Cells
- Causes: Decreased
- Hypo-IgG
- Protein losing Enteropathy
- Nephrotic Syndrome
- Causes: Increased
- Chronic granulomatous infection
- Inflammation
- Multiple Myeloma
- Liver disease
- Infections
- Autoimmune Disease
- References
- Bakerman (1984) ABCs of Lab Data, p. 252-3