Infectious Disease Book


Immunoglobulin E

Aka: Immunoglobulin E, IgE Immunoglobulin, Gamma Globulin E, IgE
  1. Lab: Normal
    1. Range: <25 ug/dl
    2. Varies by age
  2. Physiology
    1. Long stem (Fc) monomeric Antibody with Molecular weight 180,000 dalton
    2. Serum half-life of 2.5 days
    3. Reacts to allergans (Type 1 Hypersensitivity) and Parasitic Infections
  3. Causes: Decreased
    1. Congenital Hypogammaglobulinemia
    2. Acquired Hypogammaglobulinemia
    3. Sex-linked Hypogammaglobulinemia
    4. Ataxia-Telangiectasia
    5. IgE Deficiency
  4. Causes: Increased
    1. Allergic disorders
      1. Asthma
      2. Allergic Rhinitis or Hayfever
      3. Inhalant allergy
      4. Atopic Rhinitis or Sinusitis
      5. Atopic Dermatitis
      6. Urticaria
      7. Bronchopulmonary Aspergillus
      8. Hypersensitivity pneumonitis
      9. Drug Allergy
      10. Food Allergy
    2. Parasitic Infection
      1. Ascariasis
      2. Visceral Larva Migrans
      3. Toxocara
      4. Capillariasis
      5. Echinococcosis
      6. Hookworm (Necator)
      7. Amebiasis
    3. Immunologic disorders
      1. Hyper-IgE, Recurrent Pyoderma (Job-Buckley Syndrome)
      2. Thymic dysplasia or deficiency
      3. Wiskott-Aldrich Syndrome
      4. Pemphigoid
      5. Periarteritis Nodosa
      6. Hypereosinophilic Syndrome
    4. Neoplasm (i.e. IgE Myeloma)
  5. References
    1. Bakerman (1984) ABCs of Lab Data, p. 252-3

Immunoglobulin E (C0020846)

Definition (CHV) a kind of antibody that plays an important role in allergy
Definition (CHV) a kind of antibody that plays an important role in allergy
Definition (CHV) a kind of antibody that plays an important role in allergy
Definition (NCI) An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen. In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general.
Definition (MSH) An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Definition (CSP) found on the surface membrane of basophils and mast cells in all individuals; may play a role in active immunity to helminthic parasites but in developed countries it is more commonly associated with immediate hypersensitivity diseases such as asthma and hay fever.
Concepts Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129)
MSH D007073
SnomedCT 165944005, 48583005
LNC LP14671-9, MTHU004561
English IgE, Immunoglobulins, E, Immunoglobulin E, Immunoglobulin E [Chemical/Ingredient], immunoglobulins e, immunoglobulin e, immunoglobulin E (IgE), E, Immunoglobulin, Immunoglobulin IgE (substance), Immunoglobulin E (substance), Immunoglobulin IgE, immunoglobulin E, IgE - Immunoglobulin E, Immunoglobulin IgE, NOS
Swedish Immunglobulin E
Czech IgE, imunoglobulin E
Finnish Immunoglobuliini E
Italian IgE, Immunoglobulina E
Japanese 免疫グロブリンE
Polish Immunoglobulina E
Spanish inmunoglobulina IgE, inmunoglobulina E, inmunoglobulina E (sustancia), inmunoglobulina IgE (sustancia), IgE, Inmunoglobulina E
French IgE, Immunoglobuline E
German IgE, Immunglobulin E
Portuguese IgE, Imunoglobulina E
Derived from the NIH UMLS (Unified Medical Language System)

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