Infectious Disease Book

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Chlamydia Antigen

Aka: Chlamydia Antigen, Chlamydia Trachomatis Antigen, Chlamydia Polymerase Chain Reaction, Chlamydia Trachomatis PCR, Chlamydia PCR, Chlamydia Nucleic Acid Amplification Test, Chlamydia Trachomatis NAAT, Chlamydia DNA Probe, Chlamydia Rapid Point-Of-Care Test
  1. See Also
    1. Chlamydia trachomatis
  2. Indication
    1. Chlamydia screening in symptomatic and asymptomatic patients
  3. Background
    1. Chlamydia Antigen testing has replaced Chlamydia culture
    2. Nucleic Acid Amplification Tests (NAAT, PCR) are the primary tests used in the U.S. for Chlamydia detection
  4. Precautions
    1. Avoid rapid point-of-care Chlamydia tests (very low accuracy, see below)
  5. Labs
    1. Chlamydia Nucleic Acid Amplification Test (NAAT, PCR)
      1. Preferred method
    2. Older Methods
      1. Direct Fluorescent Antibody (DFA)
      2. Enzyme Immunoassay (EIA)
    3. Mechanism
      1. Detects both live and dead organisms
      2. Positive test may be seen in recent treatment
  6. Technique
    1. Same swab is used to detect both Gonorrhea and Chlamydia
    2. Eye Sample
      1. Topical Eye Anesthetic applied
      2. Swab lower and upper lids (inner surface)
    3. Urethral Samples (Males)
      1. Patient should not urinate within 1 hour before test
      2. Insert small Dacron swab 2-4 cm into Urethra
    4. Cervical Samples
      1. Wipe Cervix to remove excess mucus
      2. Insert Dacron swab into endocervix
      3. Rotate swab for 5 to 10 seconds
      4. Withdraw swabs without touching any vaginal surface
    5. Rectal Samples (symptomatic patients)
      1. Insert Dacron swab 3 cm into anal canal
      2. Withdraw swab
      3. Fecal contaminated samples should be redone
  7. Efficacy
    1. Chlamydia Nucleic Acid Amplification Tests (NAAT, PCR)
      1. Test Sensitivity: 85.5%
      2. Test Specificity: 99.6%
      3. Cook (2005) Ann Intern Med 142(11):914-25 +PMID: 15941699 [PubMed]
    2. Chlamydia DFA, EIA (older methods, replaced by PCR)
      1. Test Sensitivity: 88-91%
      2. Test Specificity: 97-99%
    3. Chlamydia Rapid Point-Of-Care Tests (avoid, very high False Negative Rate)
      1. Test Sensitivity: 38 to 58%
      2. Test Specificity: 98%
      3. Grillo-Ardila (2020) Cochrane Database Syst Rev (1):CD011708 +PMID: 31995238 [PubMed]

Chlamydia species antigen (C0368898)

Concepts Immunologic Factor (T129)
SnomedCT 121018001
LNC LP37610-0, MTHU006874
Spanish antígeno de especies de Chlamydia (sustancia), antígeno de especie de Chlamydia, antígeno de especies de Chlamydia, antígeno de especie de Chlamydia (sustancia)
English Chlamydia sp Ag, Chlamydia sp Antigen, Chlamydia species antigen (substance), Chlamydia species antigen
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Chlamydia trachomatis antigen (C0368903)

Concepts Immunologic Factor (T129)
SnomedCT 121002007
LNC LP37617-5, MTHU004207
English Chlamydia trachomatis Antigen, Chlamydia trachomatis Ag, Chlamydia trachomatis antigen (substance), Chlamydia trachomatis antigen
Spanish antígeno de Chlamydia trachomatis (sustancia), antígeno de Chlamydia trachomatis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Chlamydia trachomatis DNA:ACnc:Pt:Bld:Ord:Probe.amp.tar (C0799746)

Concepts Clinical Attribute (T201)
LNC 16599-3
English C trach DNA Bld Ql PCR, Chlamydia trachomatis DNA:ACnc:Pt:Bld:Ord:Probe.amp.tar, Chlamydia trachomatis deoxyribonucleic acid:Arbitrary Concentration:Point in time:Whole blood:Ordinal:DNA Nucleic Acid Probe.amp.tar, Chlamydia trachomatis DNA [Presence] in Blood by Probe and target amplification method
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Polymerase chain reaction for Chlamydia trachomatis (procedure) (C1275830)

Concepts Laboratory Procedure (T059)
SnomedCT 166304004, 143668007, 399193003
English Polymerase chain reaction for Chlamydia trachomatis (procedure), Chlamydia trachomatis polymerase chain reaction (procedure), Chlamydia trachomatis polymerase chain reaction, PCR test for Chlamydia trachomatis, Polymerase chain reaction for Chlamydia trachomatis
Spanish prueba de reacción de la polimerasas en cadena para Chlamydia trachomatis (procedimiento), prueba de reacción de la polimerasas en cadena para Chlamydia trachomatis
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Chlamydia PCR (C3686466)

Concepts Laboratory Procedure (T059)
SnomedCT 46261000009101
English Polymerase chain reaction for Chlamydia (procedure), Chlamydia PCR, Polymerase chain reaction for Chlamydia
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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