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Pneumococcal Vaccine
Aka: Pneumococcal Vaccine, Polyvalent pneumococcal Vaccine, Pneumovax 23, Pneumovax, Pnu-Imune 23
- See Also
- Pneumococcal Conjugate Vaccine
- Pharmacokinetics
- Purified capsular polysaccharide Antigens from 23 serotypes
- These serotypes are responsible for 88% of invasive pneumococcal disease
- Indications: Adult Vaccine
- Age 65 years and older
- Sickle Cell Disease
- Functional or anatomic Asplenia
- Administer 2 weeks prior to splenectomy
- Nephrotic Syndrome or Chronic Renal Failure
- Immunosuppression
- Human Immunodeficiency Virus
- Heart, lung or liver disease
- Asthma
- Tobacco users (starting at age 50 years)
- High risk environments
- Native American Reservations
- Nursing Homes
- Indications: Children (age 2 years and older)
- Chronic illness (including Corticosteroid dependent Asthma)
- Functional Asplenia or anatomic Asplenia
- Immunocompromised state
- Renal disease (e.g. Nephrotic Syndrome, Renal Failure)
- Dosing
- Dosing regimens are being modified in 2022 by CDC
- Prevnar 20 is sufficient alone, and does not require Pneumovax
- GIve Prevnar 20 alone (or Vaxneuvance AND Pneumovax 23)
- See Prevnar for dosing Pneumococcal Vaccine schedules
- Pneumovax 23 Indications (when Vaxneuvance or Prevnar 13 are used)
- One dose of Pneumovax 23 is sufficient for most patients at age 65 years
- Indication for single dose ages 2 to 64 years
- See Indications above
- Give a second dose at age 65 or at least 5 years after the last dose
- Indication for 2 doses at more than 5 years apart at ages 2 to 64 years
- Give third dose at age 65 years or at least 5 years after the last dose
- Chronic renal disease (Renal Failure, Nephrotic Syndrome)
- Asplenia
- Sickle Cell Anemia
- Immunocompromised state
- HIV Infection
- Leukemia
- Lymphoma
- Multiple Myeloma
- Iatrogenic (e.g. organ transplant, Radiation Therapy, Chemotherapy)
- Precautions
- Administer to high risk women before pregnancy
- ACIP recommends avoiding in pregnancy
- Pneumococcal Vaccine may be given on same day as other Vaccines (e.g. Influenza Vaccine, Shingles Vaccine)
- PrevnarVaccine may have reduced Antibody response when given with Influenza Vaccine
- However, given both Vaccines (Prevnar and Influenza) does not reduce their efficacy
- References
- Presc Lett 22(11): 63