Infectious Disease Book


Pneumococcal Vaccine

Aka: Pneumococcal Vaccine, Polyvalent pneumococcal Vaccine, Pneumovax 23, Pneumovax, Pnu-Imune 23, Pneumococcal Vaccine Indications
  1. See Also
    1. Pneumococcal Conjugate Vaccine
  2. Pharmacokinetics
    1. Purified capsular PolysaccharideAntigens from 23 serotypes
    2. These serotypes are responsible for 88% of invasive pneumococcal disease
  3. Indications: Adult Pneumococcal Vaccine Indications In General
    1. Age 65 years and older
    2. Nephrotic Syndrome or Chronic Renal Failure
    3. Heart Disease (e.g. Congestive Heart Failure, Cardiomyopathy)
    4. Liver disease
    5. Lung Disease (e.g. Asthma, COPD)
    6. Alcoholism
    7. Diabetes Mellitus
    8. Tobacco users (over age 50 years)
    9. Immunodeficiency (congenital or acquired)
      1. Generalized Malignancy
      2. Leukemia or Lymphoma
      3. Solid Organ Transplant
      4. Immunosuppression (e.g. Chemotherapy, transplant, longterm ImmunosuppressionCorticosteroids)
      5. Human Immunodeficiency Virus
      6. Sickle Cell Disease or other Hemoglobinopathy
      7. Functional or anatomic Asplenia
        1. Administer 2 weeks prior to splenectomy
    10. Anatomic abnormalities
      1. Cerebrospinal Fluid Leak
      2. Cochlear Implant
    11. High risk environments
      1. Native American Reservations
      2. Nursing Homes
  4. Indications: Children (age 2 years and older, in addition to Prevnar that is given in Primary Series)
    1. Chronic illness (including Corticosteroid dependent Asthma)
    2. Functional Asplenia or anatomic Asplenia
    3. Immunocompromised state
    4. Renal disease (e.g. Nephrotic Syndrome, Renal Failure)
  5. Dosing
    1. Dosing regimens are being modified in 2022 by CDC
      1. Prevnar 20 is sufficient alone, and does not require Pneumovax
      2. GIve Prevnar 20 alone (or Vaxneuvance AND Pneumovax 23)
    2. See Prevnar for dosing Pneumococcal Vaccine schedules
    3. Pneumovax 23 Indications (when Vaxneuvance or Prevnar 13 are used)
      1. One dose of Pneumovax 23 is sufficient for most patients at age 65 years
      2. Indication for single dose ages 2 to 64 years
        1. See Indications above
        2. Give a second dose at age 65 or at least 5 years after the last dose
      3. Indication for 2 doses at more than 5 years apart at ages 2 to 64 years
        1. Give third dose at age 65 years or at least 5 years after the last dose
        2. Chronic renal disease (Renal Failure, Nephrotic Syndrome)
        3. Asplenia
        4. Sickle Cell Anemia
        5. Immunocompromised state
          1. HIV Infection
          2. Leukemia
          3. Lymphoma
          4. Multiple Myeloma
          5. Iatrogenic (e.g. organ transplant, Radiation Therapy, Chemotherapy)
  6. Precautions
    1. Administer to high risk women before pregnancy
    2. ACIP recommends avoiding in pregnancy
    3. Pneumococcal Vaccine may be given on same day as other Vaccines (e.g. Influenza Vaccine, Shingles Vaccine)
      1. PrevnarVaccine may have reduced Antibody response when given with Influenza Vaccine
      2. However, given both Vaccines (Prevnar and Influenza) does not reduce their efficacy
  7. References
    1. Presc Lett 22(11): 63
    2. Kobayashi (2022) MMWR Morb Mortal Wkly Rep 71(4): 109-17 [PubMed]

Pneumovax (C0071315)

Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D022242
French Pneumovax
English pneumovax, Pneumovax
Derived from the NIH UMLS (Unified Medical Language System)

Polyvalent pneumococcal vaccine (C0305065)

Definition (HL7V3.0) <p>pneumococcal polysaccharide vaccine</p>
Definition (NCI) An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years.
Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D022242
SnomedCT 70447008, 135642004, 417011002
HL7 109, 33
English pneumococcal polyvalent vaccine, pneumococcal polysaccharide vaccine, pneumococcal polysaccharide vaccine (medication), Pneumococcal Polysaccharide Vaccine [Chemical/Ingredient], Polysaccharide Vaccine, Pneumococcal, Vaccine, Pneumococcal Polysaccharide, PPSV, Polyvalent pneumococcal vaccine, Pneumococcal polysaccharide vaccine (product), Pneumococcal polysaccharide vaccine, Polyvalent pneumococcal vaccine (product), Polyvalent pneumococcal vaccine (substance), Pneumococcal Polyvalent Vaccine, Pneumococcal Polysaccharide Vaccine, pneumococcal, NOS, pneumococcal, Pneumococcal polysaccharide vaccine (substance), PNEUMOCOCCAL POLYSACCHARIDE VACCINE, Pneumococcal Vaccine Polyvalent
Czech pneumokoková polysacharidová vakcína
Portuguese Vacina de Polissacarídeo de Pneumococos
Spanish Vacuna Polisacarida Neumococica, vacuna antineumocócica polisacárida (producto), vacuna antineumocócica polisacárida, vacuna antineumocócica polivalente (producto), vacuna antineumocócica polivalente (sustancia), vacuna antineumocócica polivalente, vacuna de polisacárido neumocócico (sustancia), vacuna de polisacárido neumocócico
French Vaccin antipneumococcique polysaccharidique, Vaccin pneumococcique polysaccharidique
German Pneumokokken-Polysaccharid-Vakzine, Pneumokokken-Polysaccharid-Impfstoff
Derived from the NIH UMLS (Unified Medical Language System)

Pneumococcal vaccine (C0358314)

Definition (NCI) A bacterial vaccine used to prevent contraction of Streptococcus pneumonia.
Definition (MSH) Vaccines or candidate vaccines used to prevent infections with STREPTOCOCCUS PNEUMONIAE.
Definition (CSP) vaccine or candidate vaccine used to prevent infections with Streptococcus pneumoniae.
Concepts Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D022242
SnomedCT 333598008, 398730001
LNC MTHU021223
English Pneumococcal vaccine, Pneumococcal Vaccine, Streptococcus pneumoniae vaccine, PNEUMOCOCCAL VACCINE, Pneumococcal Vaccines [Chemical/Ingredient], pneumococcal vaccine (medication), pneumococcal vaccine, pneumococcal vaccines, pneumoniae streptococcus vaccines, pneumoniae streptococcus vaccine, streptococcus pneumoniae vaccine, Pneumococcal Vaccines, Vaccines, Pneumococcal, Streptococcus pneumoniae Vaccine, Pneumococcal vaccines, Pneumococcal vaccine (product), Pneumococcal vaccine (substance)
Swedish Pneumokockvacciner
Spanish vacuna neumocócica, vacuna antineumocócica (sustancia), vacuna antineumocócica, vacuna anti-neumocóccica, vacuna antineumocócica (producto), vacuna neumocócica (producto), vacuna neumocócica (sustancia), Vacunas Neumococicas
Czech pneumokokové vakcíny
Finnish Pneumokokkirokotteet
Japanese ワクチン-肺炎球菌, 肺炎球菌多糖類ワクチン, 肺炎球菌ワクチン, 多糖類ワクチン-肺炎球菌
Polish Szczepionki przeciw zakażeniu pneumokokami, Szczepionki przeciw pneumokokom, Szczepionki przeciw pneumokokom polisacharydowe
Portuguese Vacinas contra Streptococcus Pneumoniae, Vacinas Pneumocócicas
French Vaccins antipneumococciques, Vaccins contre le pneumocoque, Vaccins pneumococciques
German Impfstoffe, Pneumokokken-, Pneumokokkenimpfstoffe, Pneumokokkenvakzinen
Italian Vaccini pneumococcici
Derived from the NIH UMLS (Unified Medical Language System)

Pneumovax 23 (C0947642)

Concepts Pharmacologic Substance (T121) , Carbohydrate (T118) , Immunologic Factor (T129)
English Pneumovax 23, Pneumovax 23 (obsolete)
Derived from the NIH UMLS (Unified Medical Language System)

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