Hematology and Oncology Book




  • Leiomyosarcoma





Aka: Leiomyosarcoma
  1. See Also
    1. Uterine Leiomyoma
    2. Soft Tissue Mass
  2. Epidemiology
    1. Onset typically over age 55 years (although younger ages may be affected)
  3. Pathophysiology
    1. Malignant variant of leiomyoma (e.g. Uterine Fibroid)
    2. Aggressive, Smooth Muscle connective tissue tumor
    3. Neoplastic spindle cell proliferation
  4. Findings
    1. Expanding mass on the limbs, head, neck, Abdomen or retroperioneum
    2. Symptoms are related to location of mass (e.g. Abdominal Pain)
  5. Imaging
    1. CT with Contrast
      1. Heterogeneous mass
  6. Management
    1. Refer for core needle biopsy and surgical resection
  7. References
    1. Achar (2022) Am Fam Physician 105(6): 602-12 [PubMed]

leiomyosarcoma (C0023269)

Definition (NCI_CDISC) A malignant neoplasm, originating from smooth muscle cells.
Definition (NCI) An uncommon, aggressive malignant smooth muscle neoplasm, usually occurring in post-menopausal women. It is characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid, granular cell, inflammatory and myxoid leimyosarcomas.
Definition (NCI_NCI-GLOSS) A malignant (cancer) tumor of smooth muscle cells that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis.
Definition (MSH) A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
Definition (CSP) sarcoma containing large spindle cells of smooth muscle; although it rarely occurs in soft tissue, it is common in the viscera; the most common soft tissue sarcoma of the uterus and retroperitoneal region.
Concepts Neoplastic Process (T191)
MSH D007890
ICD10 M8890/3
SnomedCT 51549004, 443719001, 189790006
English Leiomyosarcoma, Leiomyosarcomas, Leiomyosarcoma, no subtype (morphologic abnormality), Leiomyomosarcoma, no subtype (morphologic abnormality), Leiomyosarcoma NOS, [M]Leiomyosarcoma NOS, leiomyosarcoma (diagnosis), Leiomyosarcoma, no subtype, Leiomyosarcoma (disorder), Leiomyosarcoma [Disease/Finding], leiomyosarcomas, [M]Leiomyosarcoma NOS (morphologic abnormality), LEIOMYOSARCOMAS, LEIOMYOSARCOMA, MALIGNANT, Leiomyosarcoma - not uterine, Leiomyosarcoma (excluding uterine leiomyosarcoma), LMS - Leiomyosarcoma, Leiomyosarcoma, NOS, leiomyosarcoma
Spanish morfología: leiomiosarcoma, no clasificado como subtipo, Leiomiosarcoma NEOM, leiomiosarcoma (trastorno), [M]leiomiosarcoma, SAI (anomalía morfológica), [M]leiomiosarcoma, SAI, leiomiosarcoma, morfología: leiomiosarcoma, no clasificado como subtipo (anomalía morfológica), Leiomosarcomas, Leiomiosarcoma
Italian Leiomiosarcomi, Leiomiosarcoma NAS, Leiomiosarcoma
Dutch leiomyosarcoom NAO, leiomyosarcomata, leiomyosarcoom, Leiomyosarcoom, Sarcoom, leiomyo-
French Léiomyosarcome SAI, Léiomyosarcomes, Léiomyosarcome
German Leiomyosarkom NNB, Leiomyosarkome, Leiomyosarkom
Portuguese Leiomiossarcoma NE, Leiomiosarcoma, Leiomiossarcoma
Japanese 平滑筋肉腫NOS, 平滑筋肉腫, ヘイカツキンニクシュ, ヘイカツキンニクシュNOS
Swedish Leiomyosarkom
Czech leiomyosarkom, Leiomyosarkomy, Leiomyosarkom NOS, Leiomyosarkom
Finnish Leiomyosarkooma
Polish Mięśniakomięsak gładkokomórkowy
Hungarian Leiomyosarcomák, Leiomyosarcoma, Leiomyosarcoma k.m.n.
Norwegian Leiomyosarkom
Derived from the NIH UMLS (Unified Medical Language System)

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