Hematology and Oncology Book



Aka: Ximelagatran, Exanta, Exarta
  1. See Also
    1. Direct Thrombin Inhibitor
  2. Background
    1. No longer available (off market in U.S.) due to hepatotoxicity
    2. Listed for historical reasons only
  3. Mechanism
    1. Direct Thrombin Inhibitor
  4. Indications: Non-Valvular Atrial Fibrillation
    1. Warfarin intolerant
    2. Patients with high risk of Intracranial Hemorrhage
  5. Advantages
    1. As effective as Warfarin with INR 2-3
    2. Ximelagartan does not require monitoring
    3. Ximelagartan has fewer bleeding complications
  6. Disadvantages
    1. Expensive
    2. Myocardial Ischemia risk
    3. Risk of severe liver toxicity
  7. Dosing
    1. Studies used fixed dose of 36 mg bid
  8. References
    1. Albers (2005) JAMA 293:690-8 [PubMed]
    2. Olsson (2003) Lancet 362:1691-8 [PubMed]

ximelagatran (C0966370)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C426686
SnomedCT 415853004
English xi-melagatran, XIMELAGATRAN, ximelagatran [Chemical/Ingredient], Ximelagatran (substance), Ximelagratan, Ximelagratan (substance), Ximelagatran, glycine, N-((1)1-cyclohexyl-2-((2)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester, glycine, N-((1R)1-cyclohexyl-2-((2S)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester, ximelagatran
Spanish ximelagatrán, ximelagatrán (sustancia), ximelagratan, ximelagratan (sustancia)
Derived from the NIH UMLS (Unified Medical Language System)

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