Hematology and Oncology Book


Unfractionated Heparin

Aka: Unfractionated Heparin, Heparin
  1. See Also
    1. Low Molecular Weight Heparin
  2. Mechanism
    1. Potentiates Antithrombin III (AT III)
    2. See Intrinsic Clotting Pathway
  3. Dosing: Prophylactic for DVT Prevention
    1. Heparin 5000 Units SQ every 8-12 hours
  4. Dosing: Therapeutic Dosing by Weight based Calculations
    1. Measure
      1. Total body weight (TBW) in kilograms
      2. Height in inches
    2. Calculate Lean Body Weight (LBW) in kilograms
      1. Male: 50 + 2.3 x (height in inches - 60)
      2. Female: 45 + 2.3 x (height in inches -60)
    3. Calculate Dosing Weight
      1. Non-Obese
        1. Dosing Weight (kg): TBW above
      2. Obese (TBW > 1.4 x LBW)
        1. Dosing Weight (kg): (0.4 x TBW) + LBW
    4. Calculate Heparin starting doses
      1. Bolus: 80 Units/kg
        1. Maximum: 10,000 units
        2. Round to nearest 100 units
      2. Maintenance: 18 Units/kg/hour
        1. Round to nearest 50 units per hour
  5. Labs: Therapeutic Dosing Initial (before Heparin)
    1. Partial Thromboplastin Time (aPTT)
    2. ProTime
    3. Complete Blood Count (CBC)
  6. Labs: Therapeutic Dosing Recurring Labs
    1. Partial Thromboplastin Time (aPTT)
      1. 6 hours after bolus and then per nomogram
    2. Platelets
      1. Every 3 days
      2. Minimum: 150,000
  7. Protocol: Therapeutic Dosing Nomogram
    1. aPTT under 40
      1. Give 6000 unit bolus
      2. Increase maintenance rate by 6 units/kg/hour
      3. Recheck aPTT in 6 hours
    2. aPTT 40-49
      1. Give 3000 unit bolus
      2. Increase maintenance rate by 4 units/kg/hour
      3. Recheck aPTT in 6 hours
    3. aPTT 50-59
      1. Give 1500 unit bolus
      2. Increase maintenance rate by 2 units/kg/hour
      3. Recheck aPTT in 6 hours
    4. aPTT 60-85
      1. No change in dosing
      2. Recheck aPTT on the next morning
    5. aPTT 86-100
      1. Decrease maintenance rate by 1 unit/kg/hour
      2. Recheck aPTT in 6 hours
    6. aPTT over 100
      1. Stop Heparin for 60 minutes
      2. Decrease maintenance rate by 2 units/kg/hour
      3. Recheck aPTT in 6 hours
  8. Adverse Effects
    1. Bleeding complications
    2. Heparin Induced Thrombocytopenia
  9. Management: Reversal
    1. Protamine
Medication Costs
heparin (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
HEPARIN SODIUM 10,000 UNITS/ML VIAL Generic $2.47 per ml
HEPARIN SODIUM 5,000 UNITS/ML VIAL Generic $1.19 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Heparin (C0019134)

Definition (NCI) A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots.
Definition (NCI_NCI-GLOSS) A substance that slows the formation of blood clots. Heparin is made by the liver, lungs, and other tissues in the body and can also made in the laboratory. Heparin may be injected into muscle or blood to prevent or break up blood clots. It is a type of anticoagulant.
Definition (SPN) Enzyme preparations are products that are used in the histopathology laboratory for the following purposes: (1) To disaggregate tissues and cells already in established cultures for preparation into subsequent cultures (e.g., trypsin); (2) To disaggregate fluid specimens for cytological examination (e.g., papain for gastric lavage or trypsin for sputum liquefaction); (3) To aid in the selective staining of tissue specimens (e.g., diastase for glycogen determination).
Definition (MSH) A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Definition (CSP) poly(glucosamine sulfate-glucuronic acid); endogenous mucopolysaccharide with antithrombin and lipotropic activities; USP injection is used as an anticoagulant.
Concepts Pharmacologic Substance (T121) , Biologically Active Substance (T123) , Carbohydrate (T118)
MSH D006493
SnomedCT 372877000, 84812008, 96382006
LNC LP15998-5, LP16002-5, MTHU003766, MTHU015164
English Heparin, Heparinic Acid, heparin preparations (medication), heparin preparations, Heparin [Chemical/Ingredient], Heparin, Unfractionated, Unfractionated Heparin, unfractionated heparin, heparin unfractionated, heparins, heparin, Heparin.unfractionated, Unfractionated heparin, Heparin (product), Heparin (substance), Unfractionated heparin (substance), HEPARIN
Swedish Heparin
Czech heparin
Finnish Hepariini
Italian Acido eparinico, Eparina non frazionata, Eparina
Japanese α-ヘパリン, ヘパリン, アルファヘパリン
Croatian HEPARIN
Polish Heparyna
Spanish heparina (producto), heparina (sustancia), heparina no fraccionada (sustancia), heparina no fraccionada, heparina, Heparina, Ácido Heparínico
French Héparine
German Heparin, Heparinsäure
Portuguese Ácido Heparínico, Heparina
Derived from the NIH UMLS (Unified Medical Language System)

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