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Transfusion Associated Graft Versus Host Disease
Aka: Transfusion Associated Graft Versus Host Disease, TAGVHD
- See Also
- Transfusion Reaction
- Pathophysiology
- Donor Lymphocytes survive, engraft and react against host tissue
- Risk Factors: Severe Immunosuppresion
- Bone Marrow Transplant
- Inherited Cellular Immunity Deficiency
- Severe Lymphopenia (<300 to 500 Lymphocytes/ul)
- Signs
- Onset within 5-10 days of transfusion
- Fever
- Rash
- Nausea
- Vomiting
- Diarrhea
- Labs
- Liver function abnormalities (acute liver injury )
- Pancytopenia
- Complete marrow aplasia may occur within 21 days of transfusion
- Management
- Supportive Care
- Prevention
- Blood Product Irradiation
- Blood Product Pathogen Inactivation
- Prognosis
- Fatal in 90% of cases
- References
- Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]
- Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]