Hematology and Oncology Book



Targeted Cancer Therapy

Aka: Targeted Cancer Therapy, Cancer Immunotherapy, Biological Agent Therapy for Malignant Disease, Immuno-Chemotherapy
  1. Definition
    1. Blocks cancer cell proliferation by interfering with specific tumor-related molecules
    2. Contrast with traditional cytotoxic Chemotherapy which non-specifically targets dividing cells
  2. Types
    1. Monoclonal Antibody-Mediated Chemotherapy
    2. Small Molecule Inhibitor-Mediated Chemotherapy
  3. Complications
    1. Head and Neck
      1. Pituitary inflammation (hypophysitis)
        1. Occurs with CTLA-4 inhibitors and PD-L1 inhibitors
      2. Dry Mouth
    2. Endocrine
      1. Hypothyroidism
      2. Adrenal Insufficiency
      3. Diabetes Mellitus (autoimmune)
    3. Lung
      1. Pneumonitis
    4. Abdomen
      1. Hepatitis
      2. Pancreatitis
      3. Enterocolitis
    5. Musculoskeletal
      1. Arthralgias
    6. Skin
      1. Rash
      2. Vitiligo
  4. References
    1. Higdon (2018) Am Fam Physician 97(11):741-8 [PubMed]

Immunotherapy for cancer (C0278348)

Definition (NCI) Use of techniques, biologically active substances, and procedures to enhance or restore the ability of the host immune system to fight cancer. Also used to lessen adverse effects that may be caused by some cancer treatments.
Concepts Therapeutic or Preventive Procedure (T061)
SnomedCT 373810000, 64644003
Spanish inmunoterapia antineoplásica (procedimiento), terapia con agente biológico para enfermedad maligna, inmunoterapia contra el cáncer, immunoterapia contra el cáncer (procedimiento), inmunoterapia antineoplásica, immunoterapia contra el cáncer, tratamiento de enfermedad maligna con un agente biológico, tratamiento de enfermedad maligna con un agente biológico (procedimiento)
English cancer immunotherapies, cancer immunotherapy, immunotherapy cancer, Biological agent therapy for malignant disease (procedure), Immunotherapy for cancer, Cancer immunotherapy, Immunotherapy for cancer (procedure), Biological agent therapy for malignant disease, Immunotherapy for cancer (regime/therapy)(procedure), Cancer Immunotherapy, Immuno-Chemotherapy, Immunotherapy, Cancer, General, immunotherapy for cancer
Derived from the NIH UMLS (Unified Medical Language System)

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