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Platelet Transfusion
Aka: Platelet Transfusion, Plateletpheresis Unit, Platelet Apheresis Unit, Plateletpheresis Transfusion
- See Also
- Thrombocytopenia
- Blood Product
- Massive Hemorrhage
- Transfusion-Related Acute Lung Injury (TRALI)
- Pathophysiology
- Spontaneous endothelial bleeding does not occur until Platelet Count drops to less than 5000
- Indications: Adults
- Platelet Count <100,000
- Ocular surgery (no active bleeding)
- Neurosurgery (no active bleeding)
- Platelet Count <50,000
- Major elective surgery (not neurosurgery)
- Invasive procedure
- Elective diagnostic Lumbar Puncture
- Platelet Count <20,000
- Fever (over 100.4 F) in an otherwise stable, non-bleeding patient
- Central Venous Catheter Placement
- Platelet Count <10,000
- Stable, non-bleeding patient with hypoproliferative Thrombocytopenia
- Indications: Newborns
- Platelet Count 30,000 to 50,000
- Birth weight <1000 g and first week of life
- Cerebral Hemorrhage
- Coagulation Disorder
- Sepsis
- Invasive procedure
- Alloimmune neonatal Thrombocytopenia
- Directed donation with washed and irradiated products
- Platelet Count 20,000 to 30,000
- Active bleeding
- Lumbar Puncture
- Platelet Count <20,000
- Stable, non-bleeding patient
- Labs
- Platelet Count
- Adults: One apheresis unit (6 pack) increases platelets 30,000/ul to 50,000/ul per 2.0 m2 BSA
- Newborns: 5-10 ml/kg increases platelets 50-100,000
- Adverse Effects
- See Transfusion Complication
- See Transfusion-Related Acute Lung Injury (TRALI)
- References
- Liumbruno (2009) Blood Transfus 7(2): 132-50 [PubMed]
- Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]
- Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]