Hematology and Oncology Book



Plasma Transfusion

Aka: Plasma Transfusion, Fresh Frozen Plasma, FFP
  1. Indications
    1. Warfarin use or INR >1.6 and
      1. Active major bleeding or
      2. Intracranial Hemorrhage
      3. Prevent bleeding prior to emergent major procedure or
      4. Inherited single Clotting Factor deficiency with no available safe factors available
    2. Acute Disseminated Intravascular Coagulation (DIC) with active bleeding (FFP only, not thawed plasma)
    3. Microvascular bleeding during Massive Transfusion (>1 Blood Volume or 5L blood in a 70 kg male)
    4. Replacement fluid for thrombotic microangiopathy
      1. Thrombotic Thrombocytopenic Purpura
      2. Hemolytic Uremic Syndrome
    5. Hereditary Angioedema (if C1 esterase inhibitor is unavailable)
  2. Preparations
    1. Fresh Frozen Plasma
      1. Contains all Coagulation Factors
    2. Thawed Plasma
      1. May be kept at 33.8 to 42.8 F (1 to 6 C) for up to 5 days
      2. Contains all Coagulation Factors, but lower levels of factor V and factor VIII
      3. Do not use in DIC (use FFP instead)
  3. References
    1. Liumbruno (2009) Blood Transfus 7(2): 132-50 [PubMed]
    2. Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]

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