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Plasma Transfusion
Aka: Plasma Transfusion, Fresh Frozen Plasma, FFP
- Indications
- Warfarin use or INR >1.6 and
- Active major bleeding or
- Intracranial Hemorrhage
- Prevent bleeding prior to emergent major procedure or
- Inherited single Clotting Factor deficiency with no available safe factors available
- Acute Disseminated Intravascular Coagulation (DIC) with active bleeding (FFP only, not thawed plasma)
- Microvascular bleeding during Massive Transfusion (>1 Blood Volume or 5L blood in a 70 kg male)
- Replacement fluid for thrombotic microangiopathy
- Thrombotic Thrombocytopenic Purpura
- Hemolytic Uremic Syndrome
- Hereditary Angioedema (if C1 esterase inhibitor is unavailable)
- Preparations
- Fresh Frozen Plasma
- Contains all Coagulation Factors
- Thawed Plasma
- May be kept at 33.8 to 42.8 F (1 to 6 C) for up to 5 days
- Contains all Coagulation Factors, but lower levels of factor V and factor VIII
- Do not use in DIC (use FFP instead)
- References
- Liumbruno (2009) Blood Transfus 7(2): 132-50 [PubMed]
- Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]