Hematology and Oncology Book

Blood Transfusion

Coagulopathy

Cancer

Anemia

Platelet Disorders

Hemoglobinopathies

Hemolytic Disorders

Pathology and Laboratory Medicine

Lymphatic Disorders

Obstetrics Chapter related topics

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Plant Alkaloid Chemotherapy

Aka: Plant Alkaloid Chemotherapy
  1. Mechanism
    1. Vinca alkaloids
      1. Inhibits mitosis (metaphase arrest)
      2. Cause disassembly of microtubules
    2. Podophyllotoxins
      1. Block cells in S-G2 phase of cell cycle
      2. DNA degradation
      3. Nucleoside transport inhibition
      4. Mitochondrial electron transport inhibition
  2. Agents
    1. Periwinkle Plant (Vinca rosea) derivative
      1. Vinblastine (Velban)
      2. Vincristine (Oncovin)
    2. Mayapple plant (Podophyllum peltatum) derivative
      1. Etoposide (VP-16)
      2. Teniposide (VM-26)

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