Hydroxyurea

Aka: Hydroxyurea

1. Mechanism: Sickle Cell Anemia
   1. Increases production of fetal Hemoglobin (HbF) which does not sickle
2. Indications: Sickle Cell Anemia
   1. Indications in adults
      1. Sickle Cell Crisis 3 or more times in 12 months
      2. Severe or recurrent Acute Chest Syndrome
      3. Severe symptomatic chronic Anemia affecting functional status
      4. Sickle cell associated pain significantly impacting function or quality of life
   2. Indications in children over age 9 months
      1. All children over age 9 months should be offered Hydroxyurea to reduce complications
3. Contraindications
   1. Pregnancy
   2. Lactation
4. Monitoring
   1. Baseline
      1. Complete Blood Count with differential
      2. Reticulocyte Count
      3. Hemoglobin F quantitative measurement
      4. Comprehensive metabolic panel (Renal Function tests, Liver Function Tests)
      5. Pregnancy Test
   2. Labs while adjusting dose (every 4 weeks or more)
      1. Reticulocyte Count
      2. Complete Blood Count with differential and platelets
         1. Maintain Absolute Neutrophil Count (ANC) > 2,000/mm3
         2. Maintain Platelet Count >80,000/mm3
   3. Labs when cytopenia occurs (every 1 week)
      1. Reticulocyte Count
      2. Complete Blood Count with differential and platelets
   4. Periodic labs when on stable dose (every 2-3 months)
      1. Reticulocyte Count
      2. Complete Blood Count with differential and platelets
      3. Hemoglobin F quantitative measurement may be obtained to evaluate for response
5. Management
   1. Often managed in conjunction with Sickle Cell Disease specialist
   2. Trial for minimum of 6 months before assessing efficacy
   3. Encourage compliance for maximal effect
   4. Starting Doses
      1. Obtain baseline labs as above prior to initiating Hydroxyurea
      2. Arrange reliable Contraception for while on Hydroxyurea
      3. Dosing: Infants and Children
         1. Hydroxyurea 20 mg/kg daily
      4. Dosing: Adults with normal Renal Function
         1. Hydroxyurea 15 mg/kg (round up to nearest 500 mg) daily
      5. Dosing: Adults with Chronic Kidney Disease
         1. Hydroxyurea 5-10 mg/kg daily
   5. Adjusting dose
      1. See lab monitoring as above
      2. Maximum daily dose: 35 mg/kg/day
      3. Decreasing dose
         1. Indications
            1. Neutropenia (ANC <2000/mm3)
            2. Thrombocytopenia (Platelet Count <80,000/mm3)
         2. Approach
            1. Consult with specialist
            2. In some infants and children, ANC >1250/mm3 (instead of 2000/mm3) may be acceptable
            3. Increase lab monitoring to weekly as above
            4. Reduce Hydroxyurea dose by 5 mg/kg/day
      4. Increasing dose
         1. Target ANC 2000 to 4000/mm3
         2. Increase by 5 mg/kg/day increments every 8 weeks
6. Efficacy
   1. Full benefits may not be seen for the first 6 months after starting Hydroxyurea
   2. Reduces Sickle Cell Anemia mortality and hospitalizations (fewer episodes of crisis and Acute Chest Syndrome)
   3. Reduces Sickle Cell Crisis by 50%
   4. Steinberg (2003) JAMA 289:1645-51 [PubMed]
7. Resources
   1. NIH: NHLBI Evidence-Based Management of Sickle Cell Disease: Expert Panel Report, 2014
      1. https://www.nhlbi.nih.gov/health-pro/guidelines/sickle-cell-disease-guidelines
8. References
   1. Yawn (2015) Am Fam Physician 92(12): 1069-76 [PubMed]