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Glycoprotein IIB/IIIA Inhibitor
Aka: Glycoprotein IIB/IIIA Inhibitor, GP IIB/IIA Inhibitor, Abciximab, ReoPro, Tirofiban, Aggrastat, Eptifibatide, Integrilin- Indications
- Non-Q-Wave Myocardial Infarction
- High risk Unstable Angina
- Angioplasty
- Mechanism
- Inhibits Platelet aggregation
- Dosing: Abciximab (ReoPro)
- Load: 0.25 mg/kg IV bolus
- Infuse: 0.125 ug/kg/min up to 10 ug/min IV x12 hours
- Dosing: Eptifibatide (Integrilin)
- Acute Coronary Syndrome
- Load: 180 ug/kg
- Infuse: 2 ug/kg/min IV x72 hours
- Angioplasty
- Load: 135 ug/kg IV before procedure
- Infuse: 0.5 ug/kg/min IV x24 hours
- Acute Coronary Syndrome
- Dosing: Tirofiban (Aggrastat)
- Load: 0.4 ug/kg/min for 30 minutes
- Infuse: 0.1 ug/kg/min
- Infusion duration
- Acute Coronary Syndrome: 48 to 108 hours
- Angioplasty: 12 to 24 hours
tirofiban (C0247025) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C078823 |
SnomedCT | 108981004, 386953003 |
LNC | LP171644-0 |
English | N-(butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine, tirofiban, tirofiban (medication), tirofiban [Chemical/Ingredient], TIROFIBAN, Tirofiban (product), Tirofiban (substance), Tirofiban |
Spanish | tirofibán (producto), tirofibán (sustancia), tirofibán |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
eptifibatide (C0253563) |
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Definition (NCI) | A cyclical heptapeptide with anticoagulant activity. Eptifibatide selectively and reversibly binds to and blocks the platelet glycoprotein IIb/IIIa receptor. This prevents the binding of fibrinogen, von Willebrand factor, and other adhesive ligands and leads to an inhibition of platelet aggregation and prevents thrombus development. |
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | C086648 |
SnomedCT | 116065005, 386998009 |
LNC | LP171395-9 |
English | L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl-, cyclic(1-6)-disulfide, eptifibatide, eptifibatide (medication), eptifibatide [Chemical/Ingredient], Eptifibatide (product), Eptifibatide (substance), Eptifibatide, epifibatide, epifibratide, EPTIFIBATIDE |
Japanese | エプチフィバチド |
Spanish | eptifibatida (producto), eptifibatida (sustancia), eptifibatida |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
abciximab (C0288672) |
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Definition (NCI) | A Fab fragment of the chimeric monoclonal antibody 7E3 and inhibitor of the glycoprotein (GP) IIb/IIIa receptor, that blocks platelet aggregation. Abciximab binds to the GP IIb/IIIa receptor on the platelet membrane, which inhibits the binding of fibrinogen to the GP IIb/IIIa receptor. This prevents both platelet aggregation and thrombus formation. |
Concepts | Immunologic Factor (T129) , Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) |
MSH | C085843 |
SnomedCT | 391697004, 386951001, 108974006 |
LNC | LP171382-7 |
English | abciximab, abciximab (medication), MoAb 7E3, Chimeric 7E3 Fab, abciximab [Chemical/Ingredient], Abciximab - chemical (substance), Abciximab - chemical, Abciximab, Abciximab (product), Abciximab (substance), c7E3 Fab, chimeric 7E3 Fab, ABCIXIMAB |
Spanish | abciximab (producto), abciximab (sustancia), abciximab |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
ReoPro (C0592046) |
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Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | C085843 |
English | ReoPro, Reopro, reopro, Eli Lilly brand of abciximab, Lilly brand of abciximab |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Aggrastat (C0656369) |
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Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C078823 |
English | Aggrastat, aggrastat, Cahill May Roberts brand of tirofiban hydrochloride monohydrate, MSD brand of tirofiban hydrochloride monohydrate, Merck Frosst brand of tirofiban hydrochloride monohydrate, Merck Sharp & Dohme brand of tirofiban hydrochloride monohydrate, Merck brand of tirofiban hydrochloride monohydrate, Agrastat |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Integrilin (C0950902) |
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Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | C086648 |
English | Integrilin, eptifibatide (Integrilin), Integrelin, Pfizer brand of eptifibatide, GlaxoSmithKline UK brand of eptifibatide, integrelin, integrilin, Cor brand of eptifibatide, Essex brand of eptifibatide, Key brand of eptifibatide |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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