//fpnotebook.com/
Edoxaban
Aka: Edoxaban, Savaysa
- See Also
- Factor Xa Inhibitor
- Anticoagulants
- Mechanism
- Factor Xa Inhibitor
- Indications
- Atrial Fibrillation Anticoagulation
- Deep Vein Thrombosis
- However, must be started concurrently with Heparin, unlike other Factor Xa Inhibitors (Apixaban, Rivaroxaban)
- Contraindications
- Creatinine Clearance <15 ml/min/1.73m2
- Creatinine Clearance >95 ml/min/1.73m2 (lower efficacy due to high drug clearance)
- Severe Cirrhosis (Child-Pugh Class C)
- Dosing
- Standard dose: 60 mg orally daily
- Half dose indications (30 mg orally daily)
- Creatinine Clearance 15 to 50 ml/min/1.73m2 OR
- Weight <60 kg
- Pharmacokinetics
- Oral bioavailability: 62%
- Half-life: 10-14 hours
- Onset: 1-2 hours
- Renal clearance 50%
-
Drug Interactions
- Inducers
- Avoid Rifampin
- P-Glycoprotein Inhibitors
- Clarithromycin
- Dronedarone
- Itraconazole
- Ketoconazole
- Verapamil
- References
- Steinberg (2014) BMJ 348: g2116 +PMID:24733535 [PubMed]
- Wilbur (2017) Am Fam Physician 95(5): 295-302 [PubMed]