Cryoprecipitate

Aka: Cryoprecipitate

1. See Also
   1. Blood Product
   2. Prothrombin Complex Concentrate (PCC4)
   3. Emergent Reversal of Anticoagulation
2. Preparations: Cryoprecipitate
   1. Derived from thawing Fresh Frozen Plasma and collecting precipitate
   2. Contains 50 ml/unit
      1. Contains high concentrations of Fibrinogen
      2. Contains high concentrations of Factor VIII
      3. Also contains Factors V, XIII, vWF
3. Indications: Adults
   1. Post-cardiac surgery Hemorrhage (or other postoperative bleeding)
   2. Massive Hemorrhage or transfusion
   3. Hypofibrinogenemia (Fibrinogen <100-150 mg/dl)
4. Indications: Newborns
   1. Factor VIII Deficiency (if recombinant factor VIII not available)
   2. Von Willebrand Disease (if recombinant factors not available)
   3. Factor XIII deficiency
   4. Congenital Dysfibrinogenemia
   5. Congenital Fibrinogen deficiency
5. Labs: Fibrinogen
   1. Increases Fibrinogen up to 100 mg/dl per dose (15-20 ml per 5-7 kg body weight, or 10 units for 70 kg)
   2. Expect one unit to raise Fibrinogen 5-10 mg/dl
   3. Goal Fibrinogen >100 mg/dl
6. Dosing
   1. Adults: 15-20 ml per 5-7 kg body weight
      1. Typical dose: 10 units Cryoprecipitate
   2. Newborn: variable dosing starting from 2 ml/kg
7. Adverse Effects
   1. See Transfusion Complication (Transfusion Reaction)
8. References
   1. Callum (2009) Transfus Med Rev 23(3):177-88 [PubMed]
   2. Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]
   3. Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]