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Cryoprecipitate
Aka: Cryoprecipitate
- See Also
- Blood Product
- Prothrombin Complex Concentrate (PCC4)
- Emergent Reversal of Anticoagulation
- Preparations: Cryoprecipitate
- Derived from thawing Fresh Frozen Plasma and collecting precipitate
- Contains 50 ml/unit
- Contains high concentrations of Fibrinogen
- Contains high concentrations of Factor VIII
- Also contains Factors V, XIII, vWF
- Indications: Adults
- Post-cardiac surgery Hemorrhage (or other postoperative bleeding)
- Massive Hemorrhage or transfusion
- Hypofibrinogenemia (Fibrinogen <100-150 mg/dl)
- Indications: Newborns
- Factor VIII Deficiency (if recombinant factor VIII not available)
- Von Willebrand Disease (if recombinant factors not available)
- Factor XIII deficiency
- Congenital Dysfibrinogenemia
- Congenital Fibrinogen deficiency
- Labs: Fibrinogen
- Increases Fibrinogen up to 100 mg/dl per dose (15-20 ml per 5-7 kg body weight, or 10 units for 70 kg)
- Expect one unit to raise Fibrinogen 5-10 mg/dl
- Goal Fibrinogen >100 mg/dl
- Dosing
- Adults: 15-20 ml per 5-7 kg body weight
- Typical dose: 10 units Cryoprecipitate
- Newborn: variable dosing starting from 2 ml/kg
- Adverse Effects
- See Transfusion Complication (Transfusion Reaction)
- References
- Callum (2009) Transfus Med Rev 23(3):177-88 [PubMed]
- Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]
- Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]