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Cryoprecipitate
Aka: Cryoprecipitate
- Preparations
- Cryoprecipitate
- Derived from thawing Fresh Frozen Plasma and collecting precipitate
- Contains high concentrations of Factor VIII and Fibrinogen
- Indications: Adults
- Post-cardiac surgery Hemorrhage (or other postoperative bleeding)
- Massive Hemorrhage or transfusion
- Indications: Newborns
- Factor VIII Deficiency (if recombinant factor VIII not available)
- Von Willebrand Disease (if recombinant factors not available)
- Factor XIII deficiency
- Congenital Dysfibrinogenemia
- Congenital Fibrinogen deficiency
- Labs
- Fibrinogen
- Expect one unit to raise Fibrinogen 5-10 mg/dl
- Goal Fibrinogen >100 mg/dl
- Dosing
- Adults: 10 units Cryoprecipitate (typical)
- Newborn: variable dosing starting from 2 ml/kg
- References
- Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]
- Callum (2009) Transfus Med Rev 23(3):177-88 [PubMed]