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Chemotherapy
Aka: Chemotherapy, Chemotherapy Extravasation
- See Also
- Chemotherapy-Induced Vomiting
- Cancer Symptom
- Targeted Cancer Therapy
- Preparations: Traditional Chemotherapy
- Alkylating Agent
- Antimetabolite Chemotherapy
- Hormonally Active Chemotherapy
- Plant Alkaloid Chemotherapy
- Antibiotic Chemotherapy
- Miscellaneous Medication
- Amsacrine
- Asparaginase
- Hydoxyurea
- Mitoxantrone
- Mitotane (Lysodren)
- Quinacrine
- Preparations: Targeted Cancer Therapy
- See Immuno-Chemotherapy
- See Monoclonal Antibody-Mediated Chemotherapy
- See Immune Checkpoint Inhibitor
- See CAR T-Cell Therapy
- See Small Molecule Inhibitor-Mediated Chemotherapy
- Management: General
- See Cancer Symptom
- Exercise encouraged following high dose Chemotherapy
- Safe
- Prevents deconditioning
- Decreases toxic side effects of Chemotherapy
- Dimeo (1997) Blood 90:3390-4 [PubMed]
- Management: Extravasation of agents from IV
- Practice vigilent prevention
- Findings: Onset with hours of Chemotherapy
- Early: Pain, local erythema and swelling
- Later: Blanching, Blistering, discoloration and tissue necrosis
- Management: Early recognition and treatment is critical
- Immediately stop any infusion
- Leave cannula in place until management plan is established
- Apply ice to area
- Do not compress area
- Use antidotes if available
- Urgent Consultations with Oncology and Surgery
- Debridement with skin grafting may be needed
- Complications
- Scarring
- Contractures
- Amputation
- References
- Higdon (2006) Am Fam Physician 74:1873-80 [PubMed]
- Higdon (2018) Am Fam Physician 97(11):741-8 [PubMed]