Hematology and Oncology Book

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Bone Marrow Transplant

Aka: Bone Marrow Transplant, Stem Cell Transplant, Hemopoietic Stem Cell Transplant
  1. See Also
    1. Transplantation
  2. Complications: Infection
    1. T Cells function poorly after transplant for the first 100 days
      1. Higher risk of Viral Infection during this time
    2. Infections otherwise follow a pattern based on time from transplant that is similar to Solid Organ Transplant
      1. Month 1: Nosocomial infection (e.g. CAUTI, VAP, SSI)
      2. Month 1-6: Opportunistic infection (CMV, EBV, fungal and Parasitic Infections, Tuberculosis)
      3. Month 6+: Community acquired infection (e.g. Pneumonia) and opportunistic infections
  3. Complications: Allogenic - Early (first year)
    1. Graft-versus host (severe active, higher risk)
    2. Chronic Diarrhea, malabsorption and Electrolyte abnormalities
    3. Hemorrhagic cystitis
      1. Risk of Acute Renal Failure
      2. Initiate IV fluids
      3. Obtain renal Ultrasound
  4. Complications: Allogenic - Late (10 years post transplant)
    1. Graft-versus-host (chronic, residual)
    2. HPV-mediated oropharyngeal cancer
    3. Lung disease
    4. Growth Hormone Deficiency with Short Stature
    5. Hypogonadism
    6. Hypothyroidism
    7. Basal Cell Carcinoma
    8. Cirrhosis
  5. References
    1. Bhatia and Claudius in Herbert (2013) EM:Rap 13(6): 6-7
    2. Claudius, Ruttan and DeFabio in Swadron (2022) EM:Rap 22(11): 13
    3. Bhatia (2012) Pediatrics 130(6): 1141-3 [PubMed]

Bone Marrow Transplantation (C0005961)

Definition (MEDLINEPLUS)

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into red blood cells, which carry oxygen throughout the body, white blood cells, which fight infections, and platelets, which help the to blood clot.

A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. Doctors use these transplants to treat people with certain diseases, such as

Before you have a transplant, you need to get high doses of chemotherapy and possibly radiation. This destroys the faulty stem cells in your bone marrow. It also suppresses your body's immune system so that it won't attack the new stem cells after the transplant.

In some cases, you can donate your own bone marrow stem cells in advance. The cells are saved and then used later on. Or you can get cells from a donor. The donor might be a family member or unrelated person.

Bone marrow transplantation has serious risks. Some complications can be life-threatening. But for some people, it is the best hope for a cure or a longer life.

NIH: National Heart, Lung, and Blood Institute

Definition (NCI) A procedure to replace diseased or pathologic bone marrow with transplanted healthy bone marrow cells.
Definition (NCI_NCI-GLOSS) A procedure to replace bone marrow that has been destroyed by treatment with high doses of anticancer drugs or radiation. Transplantation may be autologous (an individual's own marrow saved before treatment), allogeneic (marrow donated by someone else), or syngeneic (marrow donated by an identical twin).
Definition (MSH) The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Definition (CSP) transference of bone marrow within an individual, between individuals of the same species, or between individuals of different species.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D016026
ICD9 41.00
SnomedCT 179239002, 149303000, 23719005
LNC LA4278-3
English Bone Marrow Transplantation, Grafting, Bone Marrow, Transplantation, Bone Marrow, Graft of bone marrow NOS, BONE MARROW TRANSPL, TRANSPL BONE MARROW, bone marrow transplant (treatment), bone marrow transplant, Graft of bone marrow NOS (procedure), Bone marrow transplant NOS, Bone marrow trnsplnt NOS, bone marrow grafting, bone marrow transplantations, bone marrow transplant bmt, bmt, bone marrow transplant (BMT), bone marrow transplants, bone marrow graft, Bone marrow transplant (procedure), Grafting of bone marrow NOS, Grafting of bone marrow NOS (procedure), Bone marrow--Transplantation, Bone marrow transplant, NOS, Bone marrow transplant, BMT - Bone marrow transplant, Bone marrow graft, Transplantation of bone marrow (procedure), Transplantation of bone marrow, bone marrow transplantation, transplantation, bone marrow, Transplantation of bone marrow, NOS, Bone Marrow Grafting, BMT, Bone Marrow Transplant, Marrow Transplantation, Bone marrow transplant, not otherwise specified, Transplant;bone marrow
Italian Trapianto di midollo osseo, Trapianto del midollo osseo NAS, Trapianto di midollo spinale
Dutch beenmergtransplantaat NAO, beenmergtransplantaat, Beenmergtransplantatie, Transplantatie, beenmerg-
French Greffe de moelle osseuse SAI, Greffe médullaire (procédure), Transplantation médullaire, Transplantation de moelle osseuse, Greffe de moelle osseuse (procédure), Greffe médullaire, Greffe de moelle osseuse
German Knochenmarktransplantation NNB, Knochenmarkstransplantation, Knochenmarktransplantation, Transplantation, Knochenmark-, Verpflanzung, Knochenmark-, Übertragung, Knochenmark-
Portuguese Transplante de medula óssea NE, Transplante de medula óssea, Enxerto de Medula Óssea, Transplante de Medula Óssea, Transplantação de Medula Óssea
Spanish Trasplante de médula ósea NEOM, injerto de médula ósea, SAI, injerto de médula ósea, SAI (procedimiento), trasplante de médula ósea (procedimiento), trasplante de médula ósea, Trasplante de médula ósea, Injerto de Médula Ósea, Trasplantación de Médula Ósea, Trasplante de Médula Ósea
Japanese 骨髄移植NOS, コツズイイショクNOS, コツズイイショク, 移植-骨髄, 骨髄移植, 骨髄移植術
Swedish Benmärgstransplantation
Finnish Luuytimensiirto
Russian KOSTNOGO MOZGA TRANSPLANTATSIIA, TRANSPLANTATSIIA KOSTNOGO MOZGA, PERESADKA KOSTNOGO MOZGA, КОСТНОГО МОЗГА ТРАНСПЛАНТАЦИЯ, ПЕРЕСАДКА КОСТНОГО МОЗГА, ТРАНСПЛАНТАЦИЯ КОСТНОГО МОЗГА
Czech Transplantace kostní dřeně, Transplantace kostní dřeně NOS, transplantace kostní dřeně, kostní dřeň - transplantace
Croatian KOŠTANA SRŽ, TRANSPLANTACIJA
Polish Przeszczepianie szpiku kostnego, Przeszczep szpiku, Transplantacja szpiku
Hungarian Csontvelő transzplantáció, Csontvelő transzplantáció k.m.n.
Norwegian Beinmargstransplantasjon, Benmargstransplantasjon, Transplantasjon av beinmarg, Transplantasjon, beinmarg
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Hemopoietic stem cell transplant (C0472699)

Definition (NCI) A therapeutic procedure that involves the transplantation of hematopoietic stem cells from a donor to a patient with a myeloid or lymphocytic malignancy.
Definition (MSH) Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D018380
SnomedCT 234336002
English Hematopoietic Stem Cell Transplantation, Stem Cell Transplantation, Hematopoietic, Transplantation, Hematopoietic Stem Cell, Haemopoietic stem cell transpl, Hemopoietic stem cell transpl, STEM CELL TRANSPL HEMATOPOIETIC, HEMATOPOIETIC STEM CELL TRANSPL, hematopoietic stem cell transplant, hematopoietic stem cell transplant (treatment), hematopoietic stem cell transplantation, HCT, Hematopoietic Cell Transplantation, HSCT, Hematopoietic stem cells--Transplantation, Haemopoietic stem cell transplant, Hemopoietic stem cell transplant (procedure), Transfusion of stem cells, Hemopoietic stem cell transplant
Swedish Blodstamcellstransplantation
Spanish trasplante de hemocitoblastos, transplante de hemocitoblastos, trasplante de hemocitoblastos (procedimiento), trasplante de células pluropotenciales hematopoyéticas, trasplante de células madre hematopoyéticas (procedimiento), trasplante de células precursoras hemopoyéticas, trasplante de células precursoras hemopoyéticas (procedimiento), trasplante de células madre hematopoyéticas, Trasplantación de Células Madre Hematopoyéticas, transplante de hemocitoblastos (procedimiento), Trasplantación de Célula Madre Hematopoyética, Trasplante de Células Madre Hematopoyéticas
Czech hematopoetické kmenové buňky - transplantace
Finnish Hematopoieettisten kantasolujen siirto
Russian PERIFERICHESKIKH STVOLOVYKH KLETOK TRANSPLANTATSIIA, TRANSPLANTATSIIA KROVETVORNYKH STVOLOVYKH KLETOK, KROVETVORNYKH STVOLOVYKH KLETOK TRANSPLANTATSIIA, GEMOPOETICHESKIKH STVOLOVYKH KLETOK TRANSPLANTATSIIA, STVOLOVYKH KLETOK KROVETVORNYKH TRANSPLANTATSIIA, STVOLOVYKH KLETOK KROVI TRANSPLANTATSIIA, ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, КРОВЕТВОРНЫХ СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, ПЕРИФЕРИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК КРОВЕТВОРНЫХ ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК КРОВИ ТРАНСПЛАНТАЦИЯ, ТРАНСПЛАНТАЦИЯ КРОВЕТВОРНЫХ СТВОЛОВЫХ КЛЕТОК
Japanese 血液幹細胞移植, 幹細胞移植-造血, 造血幹細胞移植, 移植-造血幹細胞
French Transplantation de cellules souches hématopoïétiques, Greffe de cellules souches hématopoïétiques (procédure), Greffe de cellules souches hématopoïétiques
Croatian HEMATOPOETSKE MATIČNE STANICE, TRANSPLANTACIJA, TRANSPLANTACIJA KRVOTVORNIH MATIČNIH STANICA
Polish Przeszczepianie obwodowych komórek pnia, Przeszczepianie krwiotwórczych komórek macierzystych, Przeszczepianie komórek pnia szpiku, Przeszczep krwiotwórczych komórek macierzystych, Transplantacja krwiotwórczych komórek macierzystych
Norwegian Stamcellestransplantasjon, hematopoetisk, Hematopoetisk stamcellestransplantasjon
Portuguese Transplantação de Células-Tronco Hematopoéticas, Transplante de Célula-Tronco Hematopoiética, Transplantação de Células-Tronco Hematopoiéticas, Transplante de Células-Tronco Hematopoiéticas, Transplante de Célula-Tronco Hematopoética, Transplante de Células-Tronco Hematopoéticas
German Transplantation hämatopoetischer Stammzellen
Italian Trapianto di cellule staminali ematopoietiche
Dutch Hemopoëtische stamceltransplantatie, Stamceltransplantatie, hemopoëtische, Transplantatie, stamcel-, hemopoëtische
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Stem cell transplant (C1504389)

Definition (MSHCZE) Přenos kmenových buněk mezi jedinci stejného druhu (TRANSPLANTACE HOMOLOGNÍ) nebo mezi různými druhy (TRANSPLANTACE HETEROLOGNÍ) nebo přenos v rámci téhož jedince (TRANSPLANTACE AUTOLOGNÍ). Zdroj a umístění kmenových buněk určuje jejich potenci či pluripotenci v souvislosti s jejich další diferenciací v různé typy buněk.
Definition (MSH) The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Definition (CSP) transfer of stem cells from one individual to another within the same species or between species, or transfer within the same individual; the source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Concepts Therapeutic or Preventive Procedure (T061)
MSH D033581
LNC LA4478-9
English Stem Cell Transplantation, Stem Cell Transplantations, Transplantation, Stem Cell, Transplantations, Stem Cell, TRANSPL STEM CELL, STEM CELL TRANSPL, cells stem transplantation, cell stem transplantation, stem cell transplantation, cells stem transplantations, stem cell transplantations, Stem cells--Transplantation, Stem Cell Transplant, Stem cell transplant
German Stammzell-Transplantation, Stammzellentransplantation, Stammzelltransplantation, Transplantation, Stammzell-
Swedish Stamcellstransplantation
Japanese カンサイボウイショク, 幹細胞移植
Finnish Kantasolujen siirto
Russian STVOLOVYKH KLETOK EMBRIONA TRANSPLANTATSIIA, STVOLOVYKH KLETOK VZROSLYKH OSOBEI TRANSPLANTATSIIA, STVOLOVYKH KLETOK TRANSPLANTATSIIA, STVOLOVYKH KLETOK PODROSTKOV TRANSPLANTATSIIA, STVOLOVYKH KLETOK PLODA TRANSPLANTATSIIA, СТВОЛОВЫХ КЛЕТОК ВЗРОСЛЫХ ОСОБЕЙ ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ПЛОДА ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ПОДРОСТКОВ ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ТРАНСПЛАНТАЦИЯ, СТВОЛОВЫХ КЛЕТОК ЭМБРИОНА ТРАНСПЛАНТАЦИЯ
Spanish Trasplante de células madres, Trasplantación de Célula Madre, Trasplantación de Células Madre, Trasplante de Células Madre
Czech Transplantace kmenových buněk, transplantace kmenových buněk, kmenové buňky - transplantace
French Transplantation de cellules souches, Greffe de cellules souches (procédure), Greffe de cellules souches
Croatian Not Translated[Stem Cell Transplantation]
Polish Przeszczepianie komórek macierzystych
Hungarian Őssejt transzplantáció
Norwegian Transplantasjon, stamcelle, Stamcelletransplantasjon
Portuguese Transplantação de Célula Madre, Transplante de células mães, Transplante de Células-Tronco, Transplantação de Células-Tronco
Dutch stamceltransplantaat, Stamceltransplantatie, Transplantatie, stamcel-
Italian Trapianto di cellule staminali
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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