Hematology and Oncology Book

Tranfusion

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Andexxa

Aka: Andexxa, Inactivated recombinant factor Xa
  1. See Also
    1. Emergent Reversal of Anticoagulation
    2. Factor Xa Inhibitor
    3. Eliquis (Apixaban)
    4. Xarelto (Rivaroxaban)
  2. Background
    1. Planned release 2018 in U.S.
  3. Mechanism
    1. Antidote for Eliquis (Apixaban) or Xarelto (Rivaroxaban), but not other Factor Xa Inhibitors
    2. Andexxa Binds Factor Xa Inhibitors
  4. Efficacy
    1. Limits progression of bleeding within 12 hours of dose (onset as early as 1 hour)
  5. Adverse Effects
    1. Expensive: $25,000 to 50,000 per patient
    2. Risk of Hypercoagulability complications (CVA, VTE)
  6. References
    1. (2018) Presc Lett 25(7): 37-8

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