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Allergic Transfusion Reaction

Aka: Allergic Transfusion Reaction, Anaphylaxis to Transfusion, Anaphylactic Transfusion Reaction
  1. See Also
    1. Transfusion Complication
    2. Blood Transfusion
    3. Platelet Transfusion
  2. Pathophysiology
    1. Immunoglobulin E (IgE) Antibody mediated reaction
  3. Causes
    1. pRBC Transfusion (0.4% of transfusions)
    2. Platelet Transfusion (4.1% of transfusions)
  4. Presentations
    1. Isolated skin involvement (mild)
    2. Anaphylaxis or Angioedema (severe)
      1. Incidence: 8 per 100,000 units Blood Product transfused
  5. Signs
    1. Onset of reaction during transfusion or within 4 hours of transfusion
  6. Management
    1. See Anaphylaxis
    2. Consider testing for IgA or Haptoglobin deficiency
      1. Associated with severe reactions including Anaphylaxis to Transfusion
  7. Prevention
    1. Washing and volume reduction of Blood Product prior to transfusion
    2. Strategies that have not been found effective
      1. Pretreatment prior to transfusion (e.g. Antihistamines, Glucocorticoids)
  8. References
    1. Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]
    2. Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]

Anaphylactic transfusion reaction (C0161840)

Concepts Pathologic Function (T046)
ICD10 T80.5
SnomedCT 79337003, 213320003
English Anaphylact.shock due to serum, anaphylactic shock due to serum, anaphylactic shock due to serum (diagnosis), Blood prodct-inducd anaphylaxs, Anaphylactic shock due to serum, Blood product-induced anaphylaxis, Anaphylactic shock due to serum (disorder), Anaphylactic transfusion reaction (disorder), Anaphylactic transfusion reaction, Anaphylactic transfusion reaction, NOS
Dutch anafylactische reactie op transfusie, Anafylactische shock door serum
French Réaction anaphylactique à la transfusion
German anaphylaktische Transfusionsreaktion, Anaphylaktischer Schock durch Serum
Italian Reazione anafilattica trasfusionale
Portuguese Reacção anafiláctica à transfusão
Spanish Reacción transfusional anafiláctica, anafilaxia inducida por hemoderivado, choque anafiláctico secundario al suero, shock anafiláctico secundario al suero, choque anafiláctico por suero, reacción anafiláctica a una transfusión (trastorno), reacción anafiláctica a una transfusión, shock anafiláctico por suero (trastorno), shock anafiláctico por suero
Japanese ｱﾅﾌｨﾗｷｼｰｾｲﾕｹﾂﾊﾝﾉｳ, アナフィラキシー性輸血反応
Czech Anafylaktická reakce na transfúzi
Korean 혈청에 의한 아나필락시스성 쇼크
Hungarian Anaphylaxiás transfusiós reakció
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Transfusion reaction due to allergens in blood (C1283787)

Concepts Disease or Syndrome (T047)
SnomedCT 361098001, 361106007, 10435004
Dutch allergische transfusiereactie
French Réaction allergique à la transfusion
German allergische Transfusionsreaktion
Italian Reazione allergica da trasfusione
Portuguese Reacção alérgica da transfusão
Spanish Reacción alérgica a una transfusión, reacción de transfusión por presencia de alérgenos en la sangre, reacción a una transfusión, causada por alérgenos en la sangre, reacción alérgica a una transfusión, reacción alérgica a la transfusión (trastorno), reacción alérgica a la transfusión, reacción alérgica transfusional, reacción transfusional por presencia de alérgenos en la sangre, reacción a la transfusión por presencia de alérgenos en la sangre (trastorno), reacción a la transfusión por presencia de alérgenos en la sangre, reacción de transfusión por presencia de alérgenos en la sangre (trastorno)
Japanese アレルギー性輸血反応, ｱﾚﾙｷﾞｰｾｲﾕｹﾂﾊﾝﾉｳ
Czech Alergická reakce na transfúzi
Hungarian Allergiás transfusiós reakció
English Allergic transfusion reaction, Transfusion reaction due to allergens in blood, Allergic transfusion reaction (disorder), Transfusion reaction due to allergens in blood (disorder)
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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