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Allergic Transfusion Reaction
Aka: Allergic Transfusion Reaction, Anaphylaxis to Transfusion, Anaphylactic Transfusion Reaction
- See Also
- Transfusion Complication
- Blood Transfusion
- Platelet Transfusion
- Pathophysiology
- Immunoglobulin E (IgE) Antibody mediated reaction
- Causes
- pRBC Transfusion (0.4% of transfusions)
- Platelet Transfusion (4.1% of transfusions)
- Presentations
- Isolated skin involvement (mild)
- Anaphylaxis or Angioedema (severe)
- Incidence: 8 per 100,000 units Blood Product transfused
- Signs
- Onset of reaction during transfusion or within 4 hours of transfusion
- Management
- See Anaphylaxis
- Consider testing for IgA or Haptoglobin deficiency
- Associated with severe reactions including Anaphylaxis to Transfusion
- Prevention
- Washing and volume reduction of Blood Product prior to transfusion
- Strategies that have not been found effective
- Pretreatment prior to transfusion (e.g. Antihistamines, Glucocorticoids)
- References
- Raval (2020) Am Fam Physician 102(1):30-8 [PubMed]
- Sharma (2011) Am Fam Physician 83(6): 719-24 [PubMed]