Hematology Medications in Pregnancy

1. See Also
   1. Medications in Pregnancy
2. Background
   1. Pregnancy Categories will be replaced on medication bottles with specific warnings and precautions by 2020 in U.S.
      1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm425317.htm
      2. Although FDA Pregnancy Categories are no longer FDA designated, they are included here
         1. As of 2018, succinct guidance (to replace ABCDX) on specific drugs in pregnancy is lacking
3. Class B: No risk in controlled animal studies
   1. Iron Sulfate - Not in Briggs (1998)
   2. Anticoagulants
      1. Enoxaparin (Lovenox)
      2. Dalteparin (Fragmin)
      3. Danaparoid (Orgaran)
      4. Heparin
4. Class C: Small risk in controlled animal studies
   1. Antiplatelet Medications
      1. Clopidogrel (Plavix) - not in Briggs (1998)
      2. Dipyridamole (Persantine)
      3. Ticlopidine (Ticlid) - not in Briggs (1998)
   2. Chemotherapeutics
      1. Asparaginase
      2. Dacarbazine
      3. Dactinomycin
      4. Interferon alfa
5. Class D: Strong evidence of risk to the human fetus
   1. Chemotherapeutics
      1. Bleomycin
      2. Cisplatin
      3. Cyclophosphamide
      4. Cytarabine
      5. Daunorubicin
      6. Doxorubicin
      7. Etoposide
      8. Fluorouracil
      9. Hydroxyurea
      10. Melphalan
      11. Mercaptopurine
      12. Methotrexate
      13. Plicamycin
      14. Tamoxifen
      15. Vinblastine
      16. Vincristine
   2. Miscellaneous Agents
      1. EDTA - Not in Briggs (1998)
      2. Penicillamine
   3. Anticoagulants
      1. Coumadin (Warfarin)
      2. Dicumarol
6. Class X: Very high risk to the human fetus
   1. Leuprolide (Lupron)
   2. Aminopterin
7. References
   1. Briggs (1998) Drugs in Pregnancy and Lactation, 5th ed
   2. Larimore (2000) Prim Care 27(1):35-53 [PubMed]