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Aplastic Anemia
Aka: Aplastic Anemia
- Epidemiology
- Median age of onset: 25 years
- Presentation: Symptoms
- Fatigue
- Fever
- Causes: Acquired
- Idiopathic (most common cause)
- Viral Infection
- Infectious Mononucleosis
- Viral Hepatitis (non-A non-B non-C)
- Human Immunodeficiency Virus
- Medications
- Cancer Chemotherapy (common cause)
- Antileukemic medications
- Nitrogen mustard
- Chloramphenicol (1 per 60,000 courses)
- Phenylbutazone
- Phenytoin (Dilantin)
- Carbamazepine
- Sulfonamide
- Sulfonylurea
- Heavy Metals (Gold, Arsenic, Mercury, bismuth)
- Quinacrine
- Chloroquine
- Antithyroid Drugs (e.g. Propylthiouracil)
- Carbonic anhydrase inhibitors (e.g. Acetazolamide)
- NSAIDs
- Antihistamines (Cimetidine, Chlorpheniramine)
- High dose Estrogen (e.g. Pregnancy)
- Immune Causes
- Eosinophilic fasciitis
- Hypoimmunoglobulinemia
- Toxins
- Radiation
- Insecticides (DDT, Lindane, Chlordane)
- Benzene (Kerosene, Carbon Tetrachloride, Chlorphenol)
- Miscellaneous
- Paroxysmal Nocturnal Hemoglobinuria
- Pregnancy
- Causes: Inherited
- Dyskeratosis congenita
- Fanconi's Anemia
- Reticular dysgenesis
- Schwachman-Diamond Syndrome
- Familial Aplastic Anemia (Preleukemia)
- Differential Diagnosis
- See Pancytopenia
- Labs
- Complete Blood Count
- See Pancytopenia
- Peripheral Smear
- See Pancytopenia
- Bone Marrow Biopsy
- Hypoplastic marrow (fat infiltration)
- Evaluation
- See Pancytopenia
- References
- Bacigalupo in Rakel (2001) Conn's Therapy, p. 366-8
- Ravel (1995) Clinical Laboratory Medicine, p. 35-6
- Young in Goldman (2000) Cecil Medicine, p. 848-53