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Serum Tumor Marker
Aka: Serum Tumor Marker, Cancer Marker, Tumor Marker
- Definition
- Serum glycoproteins associated with cancer
- Background
- Tumor Markers have very specific indications
- Tumor Markers should not be used for screening
- PSA is an exception, but its use is controversial
- Markers for screening have not improved survival
- Limited efficacy outside very specific populations
- High False Positive Rate in general population
- High False Negative Rate in early cancers
- Indications
- Alpha-fetoprotein (AFP)
- Nonseminomatous germ cell tumor monitoring
- Cirrhosis with liver mass (Hepatocellular Carcinoma)
- Cancer Antigen 27.29 (CA 27.29)
- Stage II or III Breast Cancer Monitoring
- Cancer Antigen 19-9 (CA 19-9)
- Specific pancreatic mass evaluation
- Cancer Antigen 125 (CA 125)
- Postmenopausal pelvic mass evaluation
- Ovarian Cancer monitoring
- Carcinoembryonic Antigen (CEA)
- Stage II or III Colorectal Cancer monitoring
- Human chorionic gonadotropin - beta subunit (bHCG)
- Nonseminomatous germ cell tumor monitoring
- Choriocarcinoma diagnosis and monitoring
- Microglobulin -beta 2 subunit (b2-M)
- Multiple Myeloma diagnosis and monitoring
- Prostate Specific Antigen (PSA)
- Prostate Cancer Screening and monitoring
- Adenocarcinoma in men with unknown primary
- References
- Perkins (2003) Am Fam Physician 68(6):1075-82 [PubMed]