Hematology and Oncology Book

//fpnotebook.com/

Serum Tumor Marker

Aka: Serum Tumor Marker, Cancer Marker, Tumor Marker
  1. Definition
    1. Serum glycoproteins associated with cancer
  2. Background
    1. Tumor Markers have very specific indications
    2. Tumor Markers should not be used for screening
      1. PSA is an exception, but its use is controversial
      2. Markers for screening have not improved survival
    3. Limited efficacy outside very specific populations
      1. High False Positive Rate in general population
      2. High False Negative Rate in early cancers
  3. Indications
    1. Alpha-fetoprotein (AFP)
      1. Nonseminomatous germ cell tumor monitoring
      2. Cirrhosis with liver mass (Hepatocellular Carcinoma)
    2. Cancer Antigen 27.29 (CA 27.29)
      1. Stage II or III Breast Cancer Monitoring
    3. Cancer Antigen 19-9 (CA 19-9)
      1. Specific pancreatic mass evaluation
    4. Cancer Antigen 125 (CA 125)
      1. Postmenopausal pelvic mass evaluation
      2. Ovarian Cancer monitoring
    5. Carcinoembryonic Antigen (CEA)
      1. Stage II or III Colorectal Cancer monitoring
    6. Human chorionic gonadotropin - beta subunit (bHCG)
      1. Nonseminomatous germ cell tumor monitoring
      2. Choriocarcinoma diagnosis and monitoring
    7. Microglobulin -beta 2 subunit (b2-M)
      1. Multiple Myeloma diagnosis and monitoring
    8. Prostate Specific Antigen (PSA)
      1. Prostate Cancer Screening and monitoring
      2. Adenocarcinoma in men with unknown primary
  4. References
    1. Perkins (2003) Am Fam Physician 68(6):1075-82 [PubMed]

You are currently viewing the original 'fpnotebook.com\legacy' version of this website. Internet Explorer 8.0 and older will automatically be redirected to this legacy version.

If you are using a modern web browser, you may instead navigate to the newer desktop version of fpnotebook. Another, mobile version is also available which should function on both newer and older web browsers.

Please Contact Me as you run across problems with any of these versions on the website.

Navigation Tree