Hematology and Oncology Book

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Platelet Morphology on Peripheral Smear

Aka: Platelet Morphology on Peripheral Smear, Platelet Morphology
  1. See Also
    1. Peripheral Smear
    2. Bone Marrow Aspirate
    3. Thrombocytopenia
  2. Evaluation
    1. Variants below as seen on Peripheral Smear
    2. Confirm Platelet Count
      1. Oil Immersion at 1000x Magnification
      2. Typical count: 15-20 per field
    3. Scan the slide for Platelet clumping (platelet agglutination)
      1. Associated with EDTA-activated antiplatelet antibodies
      2. Electronic undercounting (Pseudothrombocytopenia)
      3. Repeat sample in non-EDTA Anticoagulant
  3. Causes: Platelet Abnormalities
    1. Megathrombocytes (platelet >2.5 microns diameter)
      1. Accelerated platelet production
      2. Compensation fro increased platelet destruction
      3. Vitamin B12 Deficiency
      4. Myeloproliferative diseases
      5. Congenital Thrombocytopenia (e.g. Bernard-Soulier Syndrome)
      6. Immune Thrombocytopenic Purpura
    2. Megakaryocyte Fragments
      1. Myelofibrosis
    3. Platelet hypogranularity
      1. Myelodysplastic Syndrome
      2. Myelofibrosis

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