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Hand Foot Syndrome in Sickle Cell Anemia
Aka: Hand Foot Syndrome in Sickle Cell Anemia, Dactylitis in Sickle Cell Anemia- See Also
- Sickle Cell Anemia
- Transient Red Cell Aplasia
- Acute Chest Syndrome
- Acute Vaso-Occlusive Episode in Sickle Cell Anemia
- Aplastic Crisis in Sickle Cell Anemia
- Cerebrovascular Accident in Sickle Cell Anemia
- Hematuria in Sickle Cell Anemia
- Osteomyelitis in Sickle Cell Anemia
- Priapism in Sickle Cell Anemia
- Pulmonary Hypertension in Sickle Cell Anemia
- Septic Arthritis in Sickle Cell Anemia
- Sickle Cell Anemia Related Pulmonary Hypertension
- Sickle Cell Anemia with Splenic Sequestration
- Epidemiology
- Often the first vaso-Occlusion crisis finding in young children (as early as 6 months of age)
- Occurs in up to 50% of children with Sickle Cell Anemia by the age of 2 years
- Rare over age 4 years old
- Pathophysiology
- Not to be confused with Hand Foot Syndrome that occurs with certain Chemotherapy agents in non-sickle disease
- Occurs in Sickle Cell Anemia with vaso-Occlusion
- Caused by infarction of Bone Marrow
- Metacarpal or Metatarsal Bones and phalanges
- Symptoms
- Painful swelling and tenderness of either the hand or foot
- Digits may appear mildly erythematous
- Signs
- Low grade fever (variably present)
- Differential Diagnosis
- Course
- Resolves spontaneously within 1 week
- References
- Welsh and Welsh (2016) Crit Dec Emerg Med 30(11): 15-23