Hematology and Oncology Book


Intrinsic Clotting Pathway

Aka: Intrinsic Clotting Pathway, Intrinsic Clotting Cascade
  1. See Also
    1. Clotting Pathway
    2. Extrinsic Clotting Pathway
    3. Common Clotting Pathway
    4. Bleeding Disorder
  2. Pathophysiology
    1. Initiated by negatively charged surface
  3. Physiology: Pathway
    1. Factor XII converted to Factor XIIa
      1. Cofactors
        1. PK
        2. HMWK
      2. Inhibitors
        1. Heparin
        2. Antithrombin III
    2. Factor XI converted to Factor XIa
    3. Factor IX converted to Factor IXa
      1. Cofactors:
        1. Factor VIII
        2. von Willebrand's factor (vWF) carries Factor VIII
      2. Inhibitors
        1. Protein C
        2. Protein S
    4. Factor X converted to Factor Xa
    5. Joins Common Clotting Pathway

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