Hematology and Oncology Book

Hemorrhage

DIC

Hypercoagulability

Obstetrics Chapter related topics

Pharmacology Chapter related topics

Examination Chapter related topics

Cardiovascular Medicine Chapter related topics

Dermatology Chapter related topics

Platelet Disorders Chapter related topics

Pathology and Laboratory Medicine Chapter related topics

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Factor V Leiden

Aka: Factor V Leiden, Factor 5 Leiden, Activated Protein C resistance, APC Resistance
  1. Epidemiology
    1. Responsible for 20-50% of Hypercoagulable patients
    2. Incidence of Autosomal Dominant genetic defect
      1. Europeans: 15%
      2. North America: 3-5%
  2. Risks
    1. Heterozygote: 5-10 times the risk of thrombosis
    2. Homozygote: 50-100 times the risk of thrombosis
  3. Pathophysiology
    1. Factor V is a Cofactor for Factor X
    2. Defect prevents Factor V degradation by Protein C
  4. Labs
    1. Activated Protein C (APC) resistance
      1. Can not be anticoagulated when this lab run
    2. PCR for Factor V Leiden
      1. Responsible for 95% of APC Resistance
      2. Does NOT require that patient be off Anticoagulation
  5. Complications
    1. Deep Vein Thrombosis
    2. Pulmonary Embolism
    3. Myocardial Infarction

Activated Protein C Resistance (C0600433)

Definition (MSH) A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
Concepts Disease or Syndrome (T047)
MSH D020016
ICD10 D68.51
SnomedCT 421527008
LNC LP18494-2, MTHU004273
English Activated protein C resistance, Resistance to activated protein C due to Factor V Leiden (disorder), Resistance to activated protein C due to Factor V Leiden, Resistance to activated protein C due to Factor V R506Q, Activated Protein C Resistance, APC Resistance, Resistance, APC, activated protein C resistance, activated protein C resistance (diagnosis), Resistance to activated protein C, Activated Protein C Resistance [Disease/Finding], activated protein c resistance, apc resistance
Japanese 活性化プロテインＣ抵抗性, ｶｯｾｲｶﾌﾟﾛﾃｲﾝCﾃｲｺｳｾｲ, APCレジスタンス, 活性化プロテインCレジスタンス, 活性化プロテインC抵抗性
Swedish Aktiverat protein C-resistens
Czech FVL - faktor V Leiden, rezistence k aktivovanému proteinu C, APC rezistence, faktor V - leidenská mutace, Rezistence na aktivovaný protein C
Finnish APC-resistenssi
Russian BELKA C AKTIVIROVANNOGO USTOICHIVOST', PROTEINA C AKTIVIROVANNOGO REZISTENTNOST', БЕЛКА C АКТИВИРОВАННОГО УСТОЙЧИВОСТЬ, ПРОТЕИНА C АКТИВИРОВАННОГО РЕЗИСТЕНТНОСТЬ
Italian APC resistenza, Resistenza alla proteina C attivata
Spanish resistencia a proteína C activada debida a Factor V de Leiden (trastorno), resistencia a la proteina C activada debido al Factor V de Leiden (trastorno), resistencia a la proteina C activada debido al Factor V de Leiden, resistencia a proteína C activada debida a Factor V de Leiden, Resistencia a la Proteína C Activada, Resistencia a la APC, Resistencia a la PCA, RPCA, Resistencia a la proteína C activada
Polish Oporność APC, Oporność na aktywne białko C
Hungarian aktivált protein-C resistentia
French RPCa (Résistance à la PCa), RPCa (Résistance à la Protéine C activée), Résistance à la protéine C activée
Norwegian Faktor V-Leiden-mutasjon, Aktivert protein C-resistens, Resistens mot aktivert protein C
Portuguese RPCA, Resistência a proteína C activada, Resistência à APC, Resistência à Proteína C Ativada
Dutch geactiveerde eiwit C weerstand, APC-resistentie, Geactiveerde-proteïne-C-resistentie, Resistentie, geactiveerde-proteïne-C-
German Resistenz gegenueber aktiviertem Protein C, APC-Resistenz, Resistenz gegen aktiviertes Protein C
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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