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Sideroblastic Anemia
Aka: Sideroblastic Anemia, Pearson Syndrome
- See Also
- Microcytic Anemia
- Pathophysiology
- Defective heme metabolism
- Causes
- Toxin Exposure
- Alcohol Abuse
- Lead exposure
- Isoniazid
- Chloramphenicol
- Neoplasm or inflammatory disease
- Carcinoma
- Leukemia
- Lymphoma
- Rheumatoid Arthritis
- X-Linked recessive Sideroblastic Anemia
- Pearson Syndrome
- Vacuolation of marrow precursor cells
- Exocrine pancreatic dysfunction
- Labs
- Complete Blood Count
- See Hemoglobin Cutoffs for Anemia
- See Hematocrit Cutoffs for Anemia
- Mean Corpuscular Volume (MCV) <80 fl
- See MCV Cutoffs for Microcytic Anemia
- MCV cutoff varies by age and per reference
- Serum Iron increased
- Peripheral Smear
- Hypochromic Microcytic Anemia
- Bone Marrow Aspirate
- Ringed Sideroblasts
- Management
- Remove offending exposure
- Pyridoxine (variable efficacy)