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Lamivudine
Aka: Lamivudine, 3TC- See Also
- Mechanism
- Efficacy
- Very effective in combination with Zidovudine (AZT)
- Adverse Effects
- See nRTI for adverse effects attributed to the class
- Generally Well tolerated
- Similar adverse effects to Zidovudine (AZT) but much less severe
- Gastrointestinal upset
- Neutropenia
- Hepatitis B infection flares on Medication Withdrawal
- Dosing
- Adults: 150 mg twice daily or 300 mg orally daily
- References
| Medication Costs | ||
|---|---|---|
| lamivudine (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
| LAMIVUDINE 10 MG/ML ORAL SOLN | Generic | $0.33 per ml |
| LAMIVUDINE 100 MG TABLET | Generic | $5.31 each |
| LAMIVUDINE 150 MG TABLET | Generic | $1.53 each |
| LAMIVUDINE 300 MG TABLET | Generic | $3.77 each |
| LAMIVUDINE HBV 100 MG TABLET | Generic | $5.31 each |
| LAMIVUDINE-ZIDOVUDINE TABLET | Generic | $1.82 each |
| FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. | ||
Lamivudine (C0209738) |
|
|---|---|
| Definition (NCI) | A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04) |
| Definition (NCI_NCI-GLOSS) | A drug used to treat infection caused by viruses. |
| Definition (CSP) | zalcitabine analog |
| Definition (MSH) | A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. |
| Definition (PDQ) | A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42593&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42593&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1471" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114) |
| MSH | D019259 |
| SnomedCT | 108698001, 386897000 |
| LNC | LP21312-1, MTHU013847 |
| English | 3TC, 2',3' Dideoxy 3' thiacytidine, 2',3'-Dideoxy-3'-thiacytidine, 2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-, Lamivudine, THREE TC, DIDEOXYTHIACYTIDINE 002 003 003, 2'3' dideoxy 3' thiacytidine, lamivudine (medication), LAMIVUDINE, Lamivudine [Chemical/Ingredient], 3tc, lamiVUDine, LamiVUDine, 3'-Thia-2',3'-dideoxycytidine, 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone, lamivudine, Lamivudine (product), Lamivudine (substance) |
| Swedish | Lamivudin |
| Czech | lamivudin |
| Finnish | Lamivudiini |
| Russian | 2',3'-DIDEZOKSI-3'-TIATSITIDIN, LAMIVUDIN, 2',3'-ДИДЕЗОКСИ-3'-ТИАЦИТИДИН, 3TC, ЛАМИВУДИН |
| German | DREI TC, DIDESOXYTHIACYTIDIN 002 003 003, 3TC, 2'3'-Didesoxy-3'-thiacytidin, Lamivudin |
| Polish | Lamiwudyna |
| Japanese | 2',3'-ジデオキシ-3'-チアシチジン, ラミブジン |
| Spanish | lamivudina (producto), lamivudina (sustancia), lamivudina, 3TC, 2',3'-Didesoxi-3'-tiacitidina, Lamivudine |
| French | 3TC, Didésoxy-2',3' thiacytidine-3', Lamivudine |
| Italian | Lamivudina |
| Portuguese | 3TC, 2',3'-Didesoxi-3'-tiacitidina, Lamivudina |
| Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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