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Immune Reconstitution Inflammatory Syndrome
Aka: Immune Reconstitution Inflammatory Syndrome
- Pathophysiology
- Onset 2 to 12 weeks after starting Antiretroviral therapy for HIV (onset up to years after starting CART in rare cases)
- Recovering Immune System and rising CD4 Counts respond to latent infections and malignancies
- Findings
- Fever
- Lymphadenopathy
- Symptoms or signs related to underlying infection or malignancy
- Risk Factors
- Low starting CD4 Count
- Differential Diagnosis
- Antiretroviral therapy related Drug Reaction
- Management
- Treat underlying infection or malignancy
- Observation and supportive care
- Consult with HIV specialist
- In unusual cases, Antiretroviral therapy may need to be held
- References
- GoldSchmidt (2016) Am Fam Physician 94(9): 708-16 [PubMed]