Human Immunodeficiency Virus Book

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Abacavir

Aka: Abacavir, Ziagen
  1. See Also
    1. Anti-Retroviral Therapy
    2. Nucleoside Reverse Transcriptase Inhibitor
  2. Contraindications
    1. HLA-B*5701 positive state (screen in advance of starting)
      1. Associated with life-threatening hypersensitivity
  3. Mechanism
    1. Nucleoside Reverse Transcriptase Inhibitor
  4. Dosing
    1. Abacavir 300 mg PO bid
  5. Precautions
    1. Do not use unless patient is negative for HLA-B5701
      1. Risk of Hypersensitivity Reaction if HLA-B5701 positive
      2. Lucas (2007) J Antimicrob Chemother 59(4):591-3 +PMID:17317695 [PubMed]
  6. Adverse Effects
    1. Hypersensitivity (3%)
      1. Presents with Fever and Rash
      2. Associated with HLA-B*5701 positive state
      3. Mean onset 11 days after start
      4. Lethal reaction if restarted after reaction (50%)
      5. Never rechallenge Abacavir after reaction
    2. Cardiovascular risk
      1. Unclear association is being investigated
  7. Resources: Abacavir Hypersensitivity Registry
    1. Phone: 1-800-270-0425
  8. References
    1. (1998) Med Lett Drugs Ther 40(1041):115 [PubMed]
    2. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
    3. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]
Medication Costs
abacavir (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
ABACAVIR 300 MG TABLET Generic $2.13 each
ABACAVIR-LAMIVUDINE 600-300 MG Generic $20.22 each
ABACAVIR-LAMIVUDINE-ZIDOV TAB Generic $23.45 each
ziagen (on 5/18/2016 at Medicaid.Gov Pharmacy Drug pricing)
ZIAGEN 300 MG TABLET Generic $2.13 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

abacavir (C0663655)

Definition (NCI) A nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS.
Definition (CSP) carbocyclic nucleoside with anti-HIV activity.
Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C106538
SnomedCT 391696008, 387005008, 116084008
LNC LP21306-3, MTHU013841
English abacavir, abacavir [Chemical/Ingredient], AVACAVIR, 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-, (1S,4R)-, Abacavir - chemical (substance), Abacavir - chemical, ABACAVIR, Abacavir (product), Abacavir (substance), Abacavir
Spanish abacavir (producto), abacavir (sustancia), abacavir
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Ziagen (C0724476)

Concepts Pharmacologic Substance (T121) , Nucleic Acid, Nucleoside, or Nucleotide (T114)
MSH C106538
English Ziagen, GSK brand of abacavir sulfate, ziagen
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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