Gynecology Book


Endometrial Biopsy Interpretation

Aka: Endometrial Biopsy Interpretation
  1. See Also
    1. Endometrial Biopsy
    2. Abnormal Uterine Bleeding
    3. Endometrial Cancer
    4. Endometrial Hyperplasia
  2. Indications
    1. Abnormal Uterine Bleeding
  3. Interpretation: Biopsy Results - Uninterpretable
    1. Insufficient sample occurs in up to 31-51% of cases
    2. No tissue in sample occurs in 11% of samples
  4. Interpretation: Biopsy Results - Normal
    1. Atrophic endometrium
    2. Proliferative endometrium
    3. Secretory endometrium
  5. Indications: Biopsy Results - Abnormal
    1. Endometrial Cancer
    2. Endometrial Hyperplasia
      1. Cystic hyperplasia (rarely progresses to cancer)
        1. No treatment necessary
      2. Adenomatous hyperplasia (10% progresses to cancer)
        1. Intermittent or continuous Progestin
        2. Repeat biopsy in 3 to 6 months
      3. Atypical Adenomatous hyperplasia (25-50% progress)
        1. No future pregnancy planned
          1. Hysterectomy
        2. Future Fertility desired
          1. Consult with gynecology due to high risk
          2. High dose continuous Progestin
          3. Resample every 6 months
  6. References
    1. Williams (2020) Am Fam Physician 101(9): 551-6 [PubMed]

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