Gynecology Book



Aka: Yasmin, Drosperinone, Yaz, Yasminelle, Ocella, Zarah, Nextstellis
  1. See Also
    1. Oral Contraceptive
    2. Progestin
  2. Indications
    1. Contraception
  3. Contraindications
    1. Renal Insufficiency
    2. Hepatic insufficiency
    3. Adrenal Insufficiency
  4. Mechanism: Drosperinone
    1. Newer synthetic Progestin
    2. Antiandrogenic activity similar to Progesterone
    3. Lowest Androgenic Activity
      1. Marginal benefit over other low androgen OCPs
    4. Antimineralcorticoid effect (Related to Spironolactone)
      1. Only OCP Progestin with antimineralcorticoid activity
      2. Drospirenone 3 mg is equivalent to 25 mg Spironolactone
  5. Efficacy
    1. Similar to other Oral Contraceptives
  6. Formulations
    1. Yaz
      1. Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
      2. Taken for 24 active days and 4 Placebo days
    2. Yasminelle
      1. Contains 3 mg drospirenone and 20 mcg Ethinyl Estradiol
      2. Taken for 21 active days and 7 Placebo days
    3. Yasmin, Ocella or Zarah
      1. Contains 3 mg drospirenone and 30 mcg Ethinyl Estradiol
    4. Nextstellis
      1. Contains 3 mg drospirenone and 14.2 mg Estetrol (in mg, NOT mcg)
      2. Taken for 24 active days and 4 Placebo days
      3. At time of release in 2021, very expensive (approaching $200/month compared with <$10 for generics)
      4. Estetrol is a new plant-derived Estrogen (E4) formulation
        1. Based on NEST (Native Estrogen with Selective Actions in Tissues)
        2. Carries same Estrogen-related effects and contraindications
      5. References
        1. (2021) Presc Lett 28(7): 38
  7. Drug Interactions: Potassium retention effects
    1. Potassium sparing Diuretics (e.g. Spironolactone)
    2. ACE Inhibitors
    3. Angiotensin Receptor Blockers
    4. Aldosterone Antagonists
    5. Heparin
    6. Nonsteroidal Anti-inflammatory drugs
  8. Monitoring: Serum Potassium in first month
    1. Indicated if concurrent use of drugs listed above
  9. Adverse Effects
    1. See Oral Contraceptive
    2. Potassium retention (see above)
    3. May be associated with higher Thromboembolism risk
  10. Advantages
    1. May be associated with less weight gain than other OCP
    2. As effective as other OCPs in Acne Vulgaris
    3. May be useful in Polycystic Ovary Disease
      1. Spironolactone used for associated Hirsutism
  11. References
    1. (2002) Med Lett Drugs Ther 44(1133):55-7 [PubMed]
Medication Costs
yasmin (on 9/21/2016 at Medicaid.Gov Pharmacy Drug pricing)
YASMIN 28 TABLET Generic $0.86 each
yaz (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
YAZ 28 TABLET Generic $1.19 each
ocella (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
OCELLA 3 MG-0.03 MG TABLET Generic $0.86 each
zarah (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing)
ZARAH TABLET Generic $0.86 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information.

Yasmin (C0939533)

Concepts Pharmacologic Substance (T121) , Hormone (T125) , Organic Chemical (T109)
MSH C534342
English Yasmin, yasmin
Derived from the NIH UMLS (Unified Medical Language System)

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