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Third Generation Progestin
Aka: Third Generation Progestin, Norgestrel, Levonorgestrel- See Also
- Class
- 19 Nor-Testosterone Progestin: Gonane
- Preparation: dl-Norgestrel
- Relative Progestational Activity: 2.6
- Estrogenic Activity: 0
- Androgenic Activity: 4.2
- Endometrial Activity: 2.6
- Anti-Estrogen: Active
- Anabolic: Active
- Preparations
- Ethinyl Estradiol
- Lo-Ovral (0.3/30)
- Ovral (0.5/50)
- Progesterone only OCP (Mini-Pill)
- Ovrette (0.075)
- Ethinyl Estradiol
- Relative Progestational Activity: 2.6
- Preparation: Levonorgestrel
- Relative Progestational Activity: 5.3
- Estrogenic Activity: 0
- Androgenic Activity: 8.3
- Endometrial Activity: 5.1
- Anti-Estrogen: Active
- Anabolic: Active
- Preparations with Ethinyl Estradiol
- Relative Progestational Activity: 5.3
- Adverse Effects
- See Oral Contraceptive
- Higher risk of Thromboembolism than other OCPs
- References
- Cerel-Suhl (1999) Am Fam Physician 60(7):2073 [PubMed]
- Speroff (1993) Obstet Gynecol 81:1034-47 [PubMed]
- Dickey (1998) Managing Contraceptive Pill Patients
Medication Costs | ||
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Levonorgestrel/Ethinyl Estradiol (on 6/18/2017 at Walmart.com) | ||
Levonorgestrel/Ethinyl Estradiol | #28 tablets for $9.00 | $0.32 each |
levonorgestrel (on 5/17/2017 at Medicaid.Gov Pharmacy Drug pricing) | ||
LEVONORGESTREL 1.5 MG TABLET | Generic OTC | $20.94 each |
LEVONORGESTREL-ETH ESTRAD 0.15 MG-0.03 MG TABLET | Generic | $0.75 each |
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. |
Levonorgestrel (C0023566) |
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Definition (NCI) | The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium. |
Definition (NCI_NCI-GLOSS) | A form of the hormone progesterone that is made in the laboratory and used to prevent pregnancy. It is being studied in the prevention of ovarian and endometrial cancer, and in the treatment of other conditions. Levonorgestrel is a type of oral contraceptive. |
Definition (MSH) | A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. |
Definition (CSP) | a synthetic progestational hormone; can be delivered through different routes including capsules inserted under the skin as in Norplant. |
Concepts | Pharmacologic Substance (T121) , Steroid (T110) , Hormone (T125) |
MSH | D016912 |
SnomedCT | 326314005, 326422004, 126109000, 109032009 |
English | D Norgestrel, D-Norgestrel, l Norgestrel, l-Norgestrel, Levonorgestrel, Levonorgestrel [combined o/c], Levonorgestrel [progest cont], 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)-, (17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one, 13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one, 18-Methylnorethisterone, D-(-)-Norgestrel, NORGESTREL L, Levonorgestrel [combined oral contraceptive], Levonorgestrel [progestogen contraceptive], LEVONORGESTREL, levonorgestrel, levonorgestrel (medication), oral contraceptives levonorgestrel, Levonorgestrel [Chemical/Ingredient], d-norgestrel, Levonorgestrel [progestogen contraceptive] (product), Levonorgestrel [combined oral contraceptive] (product), L-norgestrel, Levonorgestrel product, Levonorgestrel (substance), Levonorgestrel preparation (product), Levonorgestrel preparation, Levonorgestrel [combined oral contraceptive] (substance), Levonorgestrel [progestogen contraceptive] (substance), Levonorgestrel preparation (substance), Levonogestrel |
Swedish | Levonorgestrel |
Czech | L-norgestrel, levonorgestrel |
Finnish | Levonorgestreeli |
Italian | D-Norgestrel, l-Norgestrel, Levonorgestrel |
Russian | L-NORGESTREL, LEVONORGESTREL, L-НОРГЕСТРЕЛ, ЛЕВОНОРГЕСТРЕЛ |
Spanish | preparado con levonorgestrel (producto), levonorgestrel (producto), preparado con levonorgestrel, levonorgestrel (anticonceptivo con progestágeno) (producto), levonorgestrel (anticonceptivo con progestágeno), levonorgestrel (anticonceptivo oral combinado) (producto), levonorgestrel (anticonceptivo oral combinado), levonorgestrel (sustancia), levonorgestrel, preparado de levonorgestrel (sustancia), Levonorgestrel, l-Norgestrel |
German | NORGESTREL L, L-Norgestrel, Levonorgestrel |
Polish | Lewonorgestrel, 1-norgestrel |
Japanese | レボノルゲストレル, 1-ノルゲストレル |
French | Lévonorgestrel, L-Norgestrel |
Portuguese | Levanogestrel, l-Norgestrel |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
Norgestrel (C0028368) |
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Definition (NCI) | A synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (NCI04) |
Definition (MSH) | A synthetic progestational agent with actions similar to those of PROGESTERONE. This racemic or (+-)-form has about half the potency of the levo form (LEVONORGESTREL). Norgestrel is used as a contraceptive, ovulation inhibitor, and for the control of menstrual disorders and endometriosis. |
Definition (PDQ) | A synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39310&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39310&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C703" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Hormone (T125) , Steroid (T110) |
MSH | D009644 |
SnomedCT | 82240008, 326440000, 326330002, 126106007 |
English | DL Norgestrel, DL-Norgestrel, Norgestrel, 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(+-)-, norgestrel, Norgestrel [combined o/c], Norgestrel [progestogen o/c], (+/-)-13-Ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one, Norgestrel [combined oral contraceptives], Norgestrel [progestogen oral contraceptive], norgestrel (medication), oral contraceptives norgestrel, NORGESTREL, Norgestrel [Chemical/Ingredient], norgestrol, dl-norgestrel, norgestrel preparation, Norgestrel [progestogen oral contraceptive] (product), Norgestrel [combined oral contraceptives] (product), (17alpha)-(+/-)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one, Norgestrel preparation, Norgestrel (substance), Norgestrel preparation (product), NORGES, Norgestrel [combined oral contraceptives] (substance), Norgestrel [progestogen oral contraceptive] (substance), Norgestrel preparation (substance) |
Swedish | Norgestrel |
Czech | norgestrel |
Finnish | Norgestreeli |
Russian | NORGESTREL, НОРГЕСТРЕЛ |
Japanese | ノルゲストレル |
Spanish | norgestrel (producto), preparado con norgestrel (producto), preparado con norgestrel, norgestrel (anticonceptivos orales combinados) (producto), norgestrel (anticonceptivos orales combinados), norgestrel (anticonceptivo oral con progestágeno), norgestrel (anticonceptivo oral con progestágeno) (producto), norgestrel (sustancia), norgestrel, preparado de norgestrel (sustancia), Norgestrel |
Croatian | NORGESTREL |
Polish | Norgestrel |
Norwegian | Not Translated[Norgestrel] |
French | Norgestrel |
German | Norgestrel |
Italian | Norgestrel |
Portuguese | Norgestrel |
Sources |
Derived from the NIH UMLS (Unified Medical Language System) |
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