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Mini-Pill
Aka: Mini-Pill, Progesterone Only OCP, Progestogen Only Oral Contraceptive, Progestin Only Pill, Progestin-Only Pill, Micronor, Nor QD, Nor-QD, Ovrette, Noriday, Nora-BE, Jolivette, Camila, Errin, Femulen, Norgeston, Microlut, Cerazette, Jencycla, Slynd
- See Also
- Oral Contraceptive
- Norethindrone
- Drospirenone
- Mechanism
- No Estrogen
- Progesterone only (typically L/L/L for Norethindrone 350 mcg)
- Low Progestational Activity
- Low Androgenic Activity
- Low Endometrial Activity
- Indications: Contraception
- Lactation
- Estrogen contraindicated
- See Oral Contraceptives
- Age over 35 years old and Tobacco use
- Migraine with Aura (risk of CVA)
- Venous Thromboembolism Risk
- Efficacy
- High failure rate compared with combination pills
- Consider more effective Progesterone-only options (Mirena IUD, Nexplanon Contraceptive Implant)
- Better efficacy then barrier methods
- Failure rates
- Perfect use: 0.5% failure rate
- Typical use: 5% failure rate
- Precautions
- Must be taken at the same time everyday (within 2 hours)
- Delay of 3 hours or more requires backup contraceptive use for 2 days
- Adverse Effects
- Ectopic Pregnancy increased Incidence
- Breakthrough Menstrual Bleeding
- Consider switching to combination Oral Contraceptive
- Preparations
- Norethindrone 350 mcg
- Micronor, Nor-QD, Nora-BE, Jolivette, Camila or Errin
- Noriday (UK)
- Norethindrone 750 mcg
- Ovrette
- Drospirenone 4 mg (Slynd)
- Released in 2019 in U.S. at $200/month
- Marketed as having more maintained efficacy after a missed pill than Norethindrone
- Does not require back-up Contraception if missed pill is taken within 24 hours
- Risk of Hyperkalemia (anti-mineralcorticoid effect)
- (2019) Presc Lett 26(10): 58
- Ethynodiol Diacetate 500 mcg
- Femulen (UK)
- Levonorgestrel 30 mcg
- Norgeston (UK)
- Microlut (Australia)
- Desogestrel 75 mcg
- Cerazette (UK)
- References
- Wikipedia
- http://en.wikipedia.org/wiki/Oral_contraceptive_formulations