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Mifepristone
Aka: Mifepristone, Mifeprex
- Mechanism
- Selective Progesterone receptor modulator acts as Progesterone receptor antagonist
- Causes Decidual necrosis and uterine contractions
- Indications
- Early Pregnancy Loss (<84 days)
- Termination of Pregnancy (<77 days)
- Non-pituitary Cushing Syndrome (Hypercortisolism)
- Contraindications
- Adrenal Insufficiency
- Chronic Corticosteroid use
- Precautions
- See Early Pregnancy Loss for combined protocol of Mifepristone with Misoprostol (Cytotec)
- Obstetric Ultrasound is typically used to confirm Early Pregnancy Loss and assess Gestational age
- Quantitative bhCG is often obtained to monitor serially to confirm completed Miscarriage
- RhoGAM is typically given for Rh Negative patients
- Mifepristone is obtained by licensed medical provider directly from manufacturer
- Dosing: Early Pregnancy Loss or Termination of Pregnancy
- Mifepristone 200 mg orally given 24-48 hours BEFORE Misoprostol 800 mcg per vagina or buccal
- Adverse Effects
- Nausea
- References
- MacNaughton (2021) Am Fam Physician 103(8) 473-80 [PubMed]